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NCT Number: NCT07026721

Comparative Analysis of RIRS Scoring System and Resorlu Unsal Stone Score (RUSS) for Predicting Stone-free Rate After Retrograde Intrarenal Surgery

Several studies have investigated the use of scoring systems for predicting stone-free rates after RIRS. Previous research has evaluated the RIRS Scoring System, RUSS, and other similar systems in different patient populations. This study was conducted to compare RIRS scoring system and Resorlu Unsal Stone Score (RUSS) for predicting stone free rate.

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Key information

Conditions

Renal Stones Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Nephrolithiasis Urogenital Diseases Urolithiasis Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal

Kathmandu, Bagmati, 44600, Nepal

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients more than 18 years of age undergoing RIRS for renal stone
  • providing informed written consent

Exclusion criteria

  • Previous renal and ureteric surgeries
  • coexisting bladder, ureteral stone

Treatment and study plan

Retrograde intrarenal surgery (RIRS)

Procedure

The intervention involves Retrograde Intrarenal Surgery (RIRS) performed using a flexible ureteroscope to access the renal collecting system via a retrograde (urethra → bladder → ureter → kidney) approach. Stones are fragmented using a holmium:YAG laser, with or without the use of a ureteral access sheath, depending on the case.

What distinguishes this intervention from others is the integration of preoperative scoring systems-specifically the RIRS Scoring System and the Resorlu Unsal Stone Score (RUSS)-to predict stone-free outcomes and guide case selection and surgical planning. Additionally, all procedures are performed by experienced endourologists following a standardized protocol, including consistent patient positioning, anesthesia, access technique, and post-operative imaging at defined intervals to assess outcomes.

Primary outcomes

  1. Correlation between the RIRS Scoring System and stone-free rate after Retrograde Intrarenal Surgery (RIRS), assessed using CT KUB

    Time frame: 12 months

  2. Correlation between the Resorlu-Unsal Stone Score (RUSS) and stone-free rate after Retrograde Intrarenal Surgery (RIRS), assessed using CT KUB

    Time frame: 12 months

Secondary outcomes

  1. Stone Burden as a Predictor of Stone-Free Rate After RIRS

    Time frame: Preoperative assessment and 1 month postoperatively for stone-free status

    Correlation between stone burden (mm²) and stone-free rate after Retrograde Intrarenal Surgery (RIRS

  2. Stone Density as a Predictor of Stone-Free Rate After RIRS

    Time frame: Preoperative assessment and 1 month postoperatively for stone-free status

    Correlation between stone density (Hounsfield Units, HU) and stone-free rate after RIRS

Sponsors and collaborators

Lead sponsor

Maharajgunj Medical Campus

Other

Registry information

Official study title

Comparative Analysis of RIRS Scoring System and Resorlu Unsal Stone Score (RUSS) for Predicting Stone-Free Rate After Retrograde Intrarenal Surgery: A Prospective Cohort Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jun 18, 2025
Registry last updated
Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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