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Completed

NCT Number: NCT02471612

Comparative Analysis of APACHE II and P-POSSUM

To compare APACHE II and P-POSSUM scoring system in emergency laparotomy.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Tata Main Hospital

Jamshedpur, Jharkhand, 831001, India

About this study

To compare APACHE II and P-POSSUM scoring system in predicting postoperative mortality in patients undergoing emergency laparotomy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients above 18 years of age undergoing emergency laparotomy at Tata Main Hospital form 01st December 2013 to 30th November 2014 will be included in the study.

Exclusion criteria

  • Patients willingly seeking referral to a different hospital

Treatment and study plan

Primary outcomes

  1. Area Under the Receiver Operating Curve (ROC) as a Measure of the Accuracy of the APACHE II and P-POSSUM Scoring Systems to Predict Mortality

    Time frame: 30 days

    Participants will be followed for the duration of hospital stay (expected average of 30 days) and mortality was noted.All patients undergoing emergency laparotomy at Tata Main Hospital form 01st December 2013 to 30th November 2014 were included in the study. All patients were scored with APACHE II and P-POSSUM scoring systems on the day of surgery. Area under the curve (AUC) is used to measure the "size" of the prediction composed by the graphic display between the 'sensitivity' and the '1-specificity' relationship. AUC can range from 0.5 to 1.0 and a result of 1.0 indicates a perfect discriminatory ability. An AUC value > 0.8 is considered good, a range between 0.60-0.80 is considered as moderate, and an AUC value < 0.60 is regarded as poor. For APACHE-II, a cut off score of >/=24 was determined; for P-POSSUM, a cut off score of >/= 63 was determined.

Secondary outcomes

  1. Length of Stay (LOS)

    Time frame: 30 days

    The mean duration of hospital stay or Length of Stay was recorded

  2. Need for Postoperative Ventilator Support

    Time frame: 30 days

    Number of patients needing post-operative ventilatory support

  3. Need for Post Operative Inotropic Support

    Time frame: 30 days

    Number of patients needing post-operative inotropic support

  4. Cardiac Morbidity (AMI or Arrhythmias Needing Treatment)

    Time frame: 30 days

    Number of patients noted to have Cardiac morbidity: Acute myocardial infarction (AMI) or arrhythmias needing treatment

  5. Number of Participants With Acute Kidney Injury (AKI)

    Time frame: 30 days

    Acute Kidney Injury (AKI) was diagnosed based on the Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) guidelines

    • Increase in Serum Creatinine (S. Cr) by ≥0.3 mg/dl (≥ 26.5 μmol/l) within 48 hours; OR
    • Increase in S. Cr to ≥1.5 times baseline, which is known or presumed to have occurred within prior 7 days; OR
    • Urine volume <0.5 ml/kg/h for 6 hours
  6. Patients Needing Re-exploration

    Time frame: 30 days

    Number of patients needing return to the operation theater for surgery for the same pathology or any other complication arising out of the initial surgery

Sponsors and collaborators

Lead sponsor

Tata Main Hospital

Other

Registry information

Official study title

Comparative Analysis of APACHE II and P-POSSUM Scoring Systems in Predicting Postoperative Mortality in Patients Undergoing Emergency Laparotomy

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jun 15, 2015
Registry last updated
Oct 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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