Community-Onset Bacteremia Due to ESBL Producing E.Coli or K.Pneumoniae in China: Prevalence, Risk Factors and Prognosis

Escherichia coli is the leading cause of community-onset gram-negative bloodstream infections. There has been a dramatic increase in the prevalence of extended-spectrum b-lactamases producing E. coli and K.pneumoniae in the community, which was considered to be exclusively a nosocomial pathogen in recent years. As a result, the treatment options for community-onset infections due to ESBL-producing E. coli or K.pneumoniae are limited and the initial empirical therapy is often ineffective and associated with increased mortality. Although there were some reports of the risk factors of community-onset ESBL producing E. coli in Spain, Korea, and Canada, few empirical data were available about China. Therefore, the investigators aim was to investigate the epidemiology, risk factors, and the hospital outcomes for patients with community-onset bacteremia caused by ESBL producing E. coli or K.pneumoniae in China.

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Key information

Conditions

Community Acquired Infection Community-Acquired Infections Infections

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sir Run Run Shaw Hospital

Hangzhou, Zhejiang, 310016, China

About this study

Eligibility criteria:

Inclusion criteria:Blood cultures demonstrated E.coli or K.pneumoniae among nonhospitalized patients or within 48 h after hospitalization.
Exclusion criteria:Patients with hospitalization in the past 1 month.

Outcome measures:

Risk factors for community-onset bacteremia due to ESBL producing E. coli or K.pneumoniae
Microbial and clinical efficacy of commonly used antibiotics for community-onset bacteremia due to ESBL producing E. coli or K.pneumoniae

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

older than 18 years old
community-onset bacteremia

Exclusion criteria

recent hospitalization within one month in any hospital

Treatment and study plan

bacteremia caused by ESBL producing E.coli or K.pneumoniae

Other

community-onset bacteremia caused by ESBL producing E.coli or K.pneumoniae

Primary outcomes

Risk factors for community-onset bacteremia caused by ESBL producing E.coli or K.pneumoniae

Time frame: one year

Sponsors and collaborators

Lead sponsor

Jian-cang Zhou M.D.

Other

Registry information

Official study title

Community-Onset Bacteremia Due to Extended-Spectrum β-Lactamase (ESBL)Producing Escherichia Coli or Klebsiella Pneumoniae in China: Prevalence, Risk Factors and Prognosis

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2015
First posted: Oct 11, 2013
Registry last updated: Nov 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed