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NCT Number: NCT06793605

Community Burden of MG Infection

Objective: To assess the burden and the transmission dynamics of Mycoplasma genitalium (MG) infection in men who have sex with men in Hong Kong.

Design and setting: involving a) a cross-sectional study (completion of an online self-administered survey, followed by self-sampling for testing in the laboratory, and performance of HIV self-test); b) a mathematical modelling study to simulate the transmission dynamics of MG infection and resistant MG infection and compare the impacts of test-and-treat strategies.

Participants: Around 920 men who have sex with men would be recruited

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Key information

Conditions

Sexually Transmitted Infection (STI) Behavior Communicable Diseases Disease Attributes Genital Diseases Homosexuality Infections Mycoplasma Genitalium Infection Pathologic Processes Pathological Conditions, Signs and Symptoms Sexual Behavior Sexuality Sexually Transmitted Diseases Urogenital Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

The Chinese University of Hong Kong

Hong Kong, 0000

Location status: Recruiting

Location contact

Ngai Sze Wong, PhD

CONTACT

[email protected]

22528862

About this study

Cross-sectional study: A total of 920 men who have sex with men aged 18 or above and normally living in Hong Kong would be recruited. Eligible participants would be asked to complete a self-administered online survey, submit self-collected urine specimen and rectal swabs for Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium testing in the laboratory, and submit HIV self-test results.

Mathematical modelling study: A compartmental model would be constructed to simulate the transmission dynamics of MG infection and resistant MG infection, and analyse the impact of different test-and-treat strategies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • men who have sex with men aged 18 or above, normally living in Hong Kong, and could communicate in written and spoken English or Chinese

Exclusion criteria

  • cannot provide consent

Treatment and study plan

Primary outcomes

  1. prevalence of MG infection

    Time frame: 1 year

    detection of MG infections in self-collected samples divided by the total number of samples collected

  2. prevalence of MG resistance mutations

    Time frame: 1 year

    detection of MG resistance mutations macrolide/fluoroquinolone in MG positive samples divided by the total number of MG positive samples

Secondary outcomes

  1. prevalence of CT infection

    Time frame: 1 year

    detection of CT infections in self-collected samples divided by the total number of samples collected

  2. prevalence of NG infection

    Time frame: 1 year

    detection of NG infections in self-collected samples divided by the total number of samples collected

  3. co-infection of STIs

    Time frame: 1 year

    number of co-infection of HIV, CT, NG, and/or MG

  4. history of STI and HIV testing

    Time frame: ever

    number of self-reported history of STI and/or HIV testing at survey

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Official study title

Community Burden of Mycoplasma Genitalium Infection and Its Implications for Test-and-treat Strategies

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Jan 27, 2025
Registry last updated
Mar 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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