Communication Strategies to Increase HPV Vaccination Intention

This research aims to identify communication strategies to improve the uptake of vaccines using an experimental design, focusing on the Human Papillomavirus (HPV) vaccine, which is highly effective in preventing HPV-related cancers. However, low HPV vaccination rates among adults remain a significant public health challenge. Although randomized controlled trials (RCTs) have demonstrated that interventions can increase vaccine uptake in children, few RCTs have been conducted on adults. To address this gap, a multidisciplinary investigative team with expertise in communication, medicine, nursing, and behavior-change intervention research, and a history of extensive collaboration, will conduct a survey experiment on a national sample of over 3,689 adults to identify the most promising theory-based messages to strengthen HPV vaccine intentions.

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Key information

Conditions

Papilloma Viral Infection Behavior Communicable Diseases Communication DNA Virus Infections Disease Attributes Genital Diseases Health Behavior Infections Papillomavirus Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Treatment Adherence and Compliance Treatment Refusal Tumor Virus Infections Urogenital Diseases Vaccination Hesitancy Vaccination Refusal Vaccine Hesitancy Virus Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

18-45 years old

Exclusion criteria

Under 18 and over 45 years old
Received HPV vaccine or unsure about receipt

Treatment and study plan

Messages

Behavioral

We will randomly assign participants in equal numbers to one of five theory-based HPV vaccine message conditions or an attention-matched control arm.

Primary outcomes

Intention to Vaccinate

Time frame: Immediately after the intervention

Validated 3-item likert scale assessing HPV vaccination intention.

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Collaborators

University of Pennsylvania

Registry information

Official study title

A Cluster Randomized Controlled Trial Testing Communication Strategies to Increase HPV Vaccination Intention: A Survey Experiment

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jan 20, 2025
Registry last updated: Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed