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OpenTrials
Completed

NCT Number: NCT04938284

Combining PAS to Non-invasive VNS

Vagus nerve stimulation (VNS) and paired associative stimulation (PAS) have been shown to have efficacy in improving the results of motor rehabilitation after stroke and spinal cord injury, respectively. Here we will investigate in healthy subjects the synergistic effect of these stimulation modalities on motor-evoked potential (MEP) potentiation.

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Key information

Conditions

Spinal Plasticity

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Helsinki University Hospital

Helsinki, Finland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • contraindications to TMS (e.g. brain pathology, implanted devices)
  • contraindications to MRI (e.g. MRI incompatible implants)
  • continuous use of CNS-active drugs
  • neurological, psychiatric or cardiovascular disease
  • drug abuse

Treatment and study plan

PAS

Device

Paired associative stimulation is a combination of non-invasive transcranial magnetic stimulation (TMS) and non-invasive peripheral nerve stimulation (PNS)

VNS

Device

Non-invasive vagus nerve stimulation delivered through cymba concha & cymba cavum of the ear.

Primary outcomes

  1. Motor evoked potential (MEP) potentiation

    Time frame: 0 minutes after the stimulation protocol

    MEPs are responses to transcranial magnetic stimulation recorded from target muscles.

  2. Motor evoked potential (MEP) potentiation

    Time frame: 30 minutes after the stimulation protocol

    MEPs are responses to transcranial magnetic stimulation recorded from target muscles.

  3. Motor evoked potential (MEP) potentiation

    Time frame: 60 minutes after the stimulation protocol

    MEPs are responses to transcranial magnetic stimulation recorded from target muscles.

  4. Motor evoked potential (MEP) potentiation

    Time frame: 90 minutes after the stimulation protocol

    MEPs are responses to transcranial magnetic stimulation recorded from target muscles.

Sponsors and collaborators

Lead sponsor

Helsinki University Central Hospital

Other

Registry information

Official study title

The Synergistic Effect of Paired Associative Stimulation and Vagus Nerve Stimulation on Motor-evoked Potential Potentiation in Healthy Subjects

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jun 24, 2021
Registry last updated
May 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.