Combining Electrical Impedance Tomography and Thoracic Ultrasound Toinvestigate Dynamic Changes

1. To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS. 2. To asses respiratory effort by diaphragmatic function, esophageal pressure, and EIT (Pendelluft phenomenon), and hyperinflammatory biomarkers, to predict P-SILI. 3. To develop predictive models for weaning success based on integrated EELI and thoracic ultrasound.

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Key information

Conditions

ARDS (Moderate or Severe) Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoma Lymphoma, Follicular Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult >18 y/o.
Patient intubated and receiving mechanical ventilation > 24 hours.
Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.

Exclusion criteria

Presence of Implanted Electronic Devices (pacemakers, implantable cardioverter-defibrillators).
Pregnancy.
No consent/inability to obtain consent and appropriate legal representative not available.

Treatment and study plan

Electrical impedance tomography

Diagnostic Test

Electrical impedance tomography (EIT)：Assessing pulmonary function in chronic lung diseases.
Lung ultrasound：Assessing diaphragm atrophy in mechanically ventilated patients.
Esophageal pressure：The work of breathing, or the energy required by respiratory muscles to meet ventilatory demands, can be directly evaluated by esophageal pressure
Oxygen consumption：Indirectly evaluated by measuring oxygen consumption (V̇O2) during mechanical ventilation The oxygen cost of breathing, reflected the increase in V̇O2 when transitioning from mechanical ventilation to spontaneous breathing, has been shown to predict weaning outcomes.

Other names: Lung ultrasound, Esophageal pressure, Oxygen consumption

Primary outcomes

ARDS

Time frame: From enrollment to the end of treatment at 1 weeks.

Correlation of LUS aeration scores and overdistension metrics (e.g., A-line prominence, reduced lung sliding) with EIT parameters, including hyperdistension (%), collapse (%), and ΔEELI.

Correlation of P-SILI risk with diaphragmatic function (ultrasound-measured excursion and thickening fraction), esophageal pressure variations (ΔPes, ΔPdi), pendelluft dynamics (phase shift, amplitude difference from EIT), and hyperinflammatory biomarkers (e.g., IL-6, IL-8).

Study contacts

Contact information is provided by the study sponsor or research team.

Yao-Wen Kuo

CONTACT

[email protected]

886+972651821

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Combining Electrical Impedance Tomography and Thoracic Ultrasound to Investigate Dynamic Changes of Respiratory Effort, and Regional & End-expiratory Lung Volume in Mechanically Ventilated Patients.

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: May 6, 2025
Registry last updated: May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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