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OpenTrials
Completed

NCT Number: NCT00508092

Combined Nerve Blockade and Local Infiltration Anesthesia in Appendectomy - A Blinded Randomized Study

The purpose of this study is to assess whether the use of local anesthetic to numb the nerves that run deeper in the abdominal wall gives better post operative pain control than just infiltrating local anesthetic to the wound edges.

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Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Royal Berkshire Hospital

Reading, Berkshire, RG1 5AN, United Kingdom

About this study

Local anesthetic is often administered during an operation to reduce post operative wound pain. Whilst this is frequently done during an appendectomy there is currently no evidence to suggest whether there is any benefit to the patient to injecting the local anesthetic deeper to block the nerves supplying abdominal wall sensation, compared to using it just in the skin around the wound.

Comparison: Post operative pain scores following appendectomy for patients given skin infiltration of local anesthetic (pre incision), compared to patients given both preincision wound infiltration and deeper field infiltration with local anesthetic(deep to external oblique).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Lanz incision appendectomy as starting procedure, including those where an alternative cause for symptoms is found at operation and those where incision is later extended/changed (these may be sub grouped at time of analysis)
  • Consent obtained

Exclusion criteria

  • Laparoscopic appendectomy
  • Appendectomy at time of laparotomy/other incision

Treatment and study plan

local anesthetic administration

Procedure

Pre incision skin infiltration with local anesthetic 0.5% bupivacaine by weight

OR

Pre incision skin infiltration and deeper field infiltration (deep to external oblique) with local anesthetic 0.5% bupivavcaine by weight

Primary outcomes

  1. Post operative pain score

    Time frame: 1 hour, 4 hours, 8 hours, 24 hours and on discharge

Secondary outcomes

  1. Post operative nausea and vomiting

    Time frame: 1 hour, 4 hours, 8 hours, 24 hours and on discharge

Sponsors and collaborators

Lead sponsor

Royal Berkshire NHS Foundation Trust

Other Gov

Registry information

Important dates

Study start
2007
First posted
Jul 27, 2007
Registry last updated
Apr 24, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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