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Completed

NCT Number: NCT01418027

Combined Intensive and Conventional Exercise on Nonalcoholic Fatty Liver Disease (NAFLD)

The prevalence of NAFLD is 50-70% in obese people. A decrease of calorie intake and increase of physical activity are recommended as an effective approach for the prevention and treatment of NAFLD. However, the exercise model for NAFLD intervention is understudied. In the present study we aim to compare the effect of intensive and conventional exercise interventions on NAFLD.

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Key information

Conditions

Non-Alcoholic Fatty Liver Disease (NAFLD) Behavior Digestive System Diseases Fatty Liver Liver Diseases Motor Activity Non-alcoholic Fatty Liver Disease

Age range

40 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

The First Hospital Affiliated to Xiamen University

Xiamen, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Subjects with NAFLD determined by MRS ;
  • Age 40-65 years old;
  • Waist circumference> 90cm for men and > 85cm for women.

Treatment and study plan

Intensive exercise

Other

Subjects conduct an aerobic exercise at 65-80% maximum oxygen consumption for 30 minutes each day, five days a week, totally for 6 months.Subsequently, moderate physical activity(3.0-6.0 MET s) at 150 min/wk for 6 months.

Conventional Exercise

Other

Subjects receive moderate physical activity(3.0-6.0 MET s) at 150 min/wk(30 min per day, five days a week) for 12 months.

Primary outcomes

  1. Change of intrahepatic triglyceride contents

    Time frame: 12 months

Secondary outcomes

  1. Change of body weight

    Time frame: 12 months

  2. Change of waist circumference

    Time frame: 12 months

  3. Change of body fat

    Time frame: 12 months

  4. Change of abdominal fat

    Time frame: 12 montshs

  5. Change of carotid intima-media thickness

    Time frame: 12 months

  6. Change of cardiovascular risk factors (Blood pressure, lipids, glucose)

    Time frame: 12 months

  7. Change of insulin resistance

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Shanghai Jiao Tong University School of Medicine

Other

Registry information

Official study title

Combined Intensive and Conventional Exercise Intervention of Nonalcoholic Fatty Liver Disease

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Aug 16, 2011
Registry last updated
Sep 1, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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