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NCT Number: NCT06610006

Combined Effects of Isometric Wall Squats and High Intensity Interval Training on Rate Pressure Product in Normotensive and Pre-hypertensive Sedentary Adults

Hypertension is leading yet preventable risk factor for cardiovascular disease and all-cause mortality worldwide. Prehypertension identifies those at high risk of developing HTN, prompting intervention to prevent or delay the onset of the disease. High intensity interval training (HIIT) is a time efficient mode of training with established benefits, while Isometric wall squats (IWS) also provide a range of proven benefits and advantages, but their combined effect on BP measures is yet to be determined.Hence the objective of this study is to compare the effects of isometric wall squats along with high intensity interval training versus high intensity interval training alone on rate pressure product, SBP and DBP, heart rate and anthropometric measures in normotensive and pre-hypertensive sedentary adults

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Pre Hypertension Cardiovascular Diseases Prehypertension Vascular Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Foundation University College of Physical Therapy

Rawalpindi, Punjab Province, 46000, Pakistan

About this study

Pre-Hypertension is not a disease itself rather it categorizes those who are at the risk of developing hypertension in future. By targeting pre-hypertensive and normotensive individuals we are focusing on preventive measures, potentially reducing incidence of HTN and cardiovascular conditions in future. If found effective, this study can help in providing training protocols while also decreasing the risk of hypertension in future.A total of 15 sessions of high intensity interval training alone in one group and combination of high intensity interval and isometric wall squat in other group, for thrice a week on alternative days for 5 consecutive weeks will be given.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both male and female adults aged 18-45 years.
  • Participants lying in Low PA (inactive) category on basis of IPAQ.
  • Pre-hypertensive adults:
  • SBP- 120 mmHg or more and <140 mmHg
  • DBP of 80 mmHg or more and < 90 mmHg.
  • Normotensive adults: SBP < 120 mmHg and DBP < 80 mmHg. Exclusion Criteria
  • Diagnosed with any current infections.
  • Subjects with any diagnosed cardiovascular or respiratory conditions.
  • Subjects with diagnosed musculoskeletal or neurological conditions which hinder participation in physical activity program.
  • Active Smokers
  • Those with any contraindication to exercise testing or training.
  • Pregnant females

Treatment and study plan

High Intensity Interval Training (HIIT)

Procedure

High intensity interval training on treadmill with moderate intensity (40-60%HRR) in week 1 to achieve the baseline fitness level and from week 2 to 5 they will progress to high intensity with setting the lower target HR 40-60%HRR and upper target HR 80-85%HRR with 1:4 work to rest ratio followed by 5-7 min of cool-down period..A total of 15 sessions of high intensity interval training alone , for thrice a week on alternative days for 5 consecutive weeks will be given. Warm-up session consisting of stretching exercises prior to intervention and cool down session after intervention will also be done and vitals before and after the session will be taken.

Isometric Wall Squat

Procedure

For isometric wall squat, each training session will be composed of 4 × 2-min bouts of IWS followed by 2-min rest periods. In first week, participants will do squat training or there will be a protocol for selecting exercise intensity in which participants will be given 30-s to perform a wall squat to select a position that they predict would elicit an target RPE score by varying the squat height. Based on the final squat height and RPE score, after bout 4, participants will be given a starting squat height for training session 1 and will then be progressed in each week

Primary outcomes

  1. Rate Pressure Product

    Time frame: 5 weeks

    Measured by multiplying Heart Rate and Systolic Blood Pressure

  2. Blood Pressure(SBP and DBP)

    Time frame: 5 weeks

    Evaluation will be done using sphygmomanometer

  3. Heart rate

    Time frame: 5 weeks

    Heart Rate will be measured using pulse oximeter.

  4. Anthropometric Measures Waist circumference

    Time frame: 5 weeks

    Measuring Tape will be used to measure Waist circumference

  5. Anthropometric Measures hip circumference

    Time frame: 5 weeks

    Measuring Tape will be used to measure hip circumference

  6. Anthropometric Measures Waist to hip ratio

    Time frame: 5 weeks

    Ratio of waist circumference and hip circumference

  7. BMI

    Time frame: 5 weeks

    Body mass index ratio of weight and height

Sponsors and collaborators

Lead sponsor

Foundation University Islamabad

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Sep 24, 2024
Registry last updated
Sep 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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