Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation

Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation

Completed

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Key information

Conditions

Corneal Perforation Corneal Diseases Corneal Injuries Craniocerebral Trauma Eye Diseases Eye Injuries Facial Injuries Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine

Minya, Egypt

About this study

Use of amniotic membrane and platelet rich plasma clot for closure of central corneal perforation either post infective or posttraumatic

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

central corneal perforation

Exclusion criteria

active infection
posterior segment pathology
non seeing eye

Treatment and study plan

Platelet rich plasma clot implantation

Procedure

Implantation of a platelet rich plasma clot, which is created from the plasma of the patients, and refrigerated to be inserted under the sealing amniotic membrane

Wound closure with amniotic membrane

Procedure

Closure of the corneal perforation with a synthetic amniotic membrane with a 2 mm safety margin

Primary outcomes

Closure of the corneal wound

Time frame: 3 months

sealing of the edges corneal gap, with formation of scar tissue

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2020
Study completion: 2020
First posted: Apr 18, 2018
Registry last updated: May 19, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed