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NCT Number: NCT06552936

Combination Therapy Effect of Laser on Wound Healing and Bone Regeneration of Dental Sockets

The goal of this clinical trial is to learn if the laser works to improve wound healing and bone regeneration after tooth extraction. The main question it aims to answer is:

Does laser therapy improve wound healing and bone regeneration after tooth extraction?

Researchers will compare a laser to sham laser therapy to see if the laser enhances wound healing and bone regeneration.

Participants will:

Have exposure to laser or sham laser therapy immediately after tooth extraction Record their pain intensity on days 2, 4, 6 and 14 Visit the clinic after 10 days for follow-up Again, visit the clinic after 4 months for evaluation

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Key information

Conditions

Tooth Extraction Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sharif Medical and Dental College, Lahore, Punjab Province, Pakistan

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 21 years old, regardless of gender
  • Non-traumatic tooth extraction of the lower jaw is indicated
  • Willing for dental implant surgery
  • Dental appointments are available at the study place
  • Absence of active infection at the extraction site
  • Signed informed permission is provided.

Exclusion criteria

  • Pregnant, lactating, and menopausal women
  • Smokers
  • Those having head and neck radiotherapy
  • Those with any sort of acute infection (e.g., periodontal abscess), immune deficiency, or metabolic conditions such as diabetes mellitus and osteoporosis
  • Patients will also be eliminated if they have a complication during surgery, such as bleeding or operational difficulties, or if the procedure takes longer than 90 minutes.

Treatment and study plan

Diode Laser 980 nm.

Other

A Diode laser is commonly used in simple surgical procedures on soft tissue, such as skin or mucosa. Its tip can work when non-activated, causing inductive effects, and when activated, it causes the ablation of soft tissue.

Primary outcomes

  1. Wound healing will be assessed in both the experimental and control groups.

    Time frame: 1 year

    Wound healing will be assessed using the Landry, Turnbull, and Howley index after 7 days, and a score will be given ranging from 1 to 5, where 1 indicates very poor healing, and 5 indicates excellent healing. (score range: 1-very poor, 2-poor, 3-good, 4-very good, 5-excellent)

  2. Bone regeneration will be assessed in both the experimental and control groups.

    Time frame: 1 year

    A postoperative cone beam computed tomography (CBCT) will be taken immediately after extraction, followed by a CBCT 4 months after extraction. The immediate CBCT will be done to study the density of healthy bone in the apical region of the extracted tooth socket. This value will serve as the baseline for further assessment. The density obtained will then be compared with the bone formed at the end of 4 months in the extraction socket with and without laser therapy. Taking mean readings in the grayscale measurements from the periapical region will allow for the calculation of bone density.

Secondary outcomes

  1. Pain intensity will be measured in both the experimental and control groups.

    Time frame: 1 year

    The Visual Analogue Scale (VAS) will assess pain intensity at post-extraction days 2, 4, 6, and 14. It consists of a 10 cm line with two endpoints representing 0 ('no pain') and 10 ('pain as bad as it could possibly be'). VAS is a system that classifies a score of 1 to 4 (on a 0-10 scale) as mild pain, 5 to 6 as moderate pain, and 7 to 10 as severe pain.

Study contacts

Contact information is provided by the study sponsor or research team.

Nauman R Khan, MPhil

CONTACT

[email protected]

+923214894164

Professor

CONTACT

[email protected]

+923215606840

Sponsors and collaborators

Lead sponsor

Sharif Medical Research Center

Other

Collaborators

  • Universiti Sains Malaysia

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 14, 2024
Registry last updated
May 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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