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Completed

NCT Number: NCT07089446

Combination of Platelets Rich Plasma and Hyaluronic is an Effective Tool for Treatment of Knee Osteoarthritis

The purpose of the study is to determine the effects of HA, PRP and the combination of HA and PRP in reducing pain and improving functional disability in patients with knee osteoarthritis.

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Key information

Conditions

Knee Osteoarthristis Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Pain Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

South City Hospital

Karachi, Sindh, 75600, Pakistan

About this study

To determine the effects of combination of platelet rich plasma (PRP) and hyaluronic acid and the PRP or HA alone in reducing pain and increasing range of motion among individuals with knee osteoarthritis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • grade II-III according to the Kellgren-Lawrence classification),
  • pain or functional limitations in patients' activity of daily living before the treatment,
  • age between 40 and 70 years of age, and the absence of clinical or imaging signs of articular instability.

Exclusion criteria

  • includes known hypersensitivity to hyaluronic acid,
  • pregnancy and lactation, a BMI greater than 40 kg/m2,
  • chronic administration of anticoagulant drugs or a history of coagulopathies,
  • neoplastic lesions, and knee or kidney failures

Treatment and study plan

Hyaluronic Acid (HA)

Drug

Hyaluronic Acid

Platelet rich plasma

Drug

Platelet rich plasma

Hyaluronic Acid (HA) and Platelet rich plasma

Drug

Hyaluronic Acid and Platelet rich plasma

Primary outcomes

  1. visual analogue scale

    Time frame: Recorded before the treatment and repeated within 3 and 6 months after the treatment.

    It is a straight line, 100 millimeters long line, one end of the line means "not at all" or "none" and the other end means "the worst possible" or "extremely".

Secondary outcomes

  1. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

    Time frame: Recorded before the treatment and repeated within 3 and 6 months after the treatment.

    It s a questionnaire used to assess pain, stiffness, and physical function in individuals with osteoarthritis, particularly of the knee. It is a self-administered, multidimensional tool that evaluates these three dimensions through a series of questions, typically on a Likert scale.

Sponsors and collaborators

Lead sponsor

University of Karachi

Other

Registry information

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Jul 28, 2025
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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