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Completed

NCT Number: NCT07133360

Combination of Mixed Drugs vs Ibuprofen: a Randomized Clinical Trial

Combination of vitamins and melatonine compared with the conventional use of ibuprofen after surgical third molar extraction

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Key information

Conditions

Swelling Lips &Amp; Face Disease Attributes Facies Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Spasm Trismus

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Complutense University of Madrid

Madrid, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers, non ibuprofen allergic, presence of impacted lower third molar

Exclusion criteria

  • Diseases that avoid surgical intervention

Treatment and study plan

Third molar extraction

Procedure

Surgical third molar extraction with conventional medication

Primary outcomes

  1. Post operative pain

    Time frame: 10 DAYS

    VAS pain scale

  2. Swelling

    Time frame: 7 DAYS

    Face measurement for swelling

  3. Trismus

    Time frame: 7 DAYS

    Opening limitation

Secondary outcomes

  1. Rescue analgesia

    Time frame: 7 DAYS

    Need for more medications

  2. Inflammatory profile

    Time frame: 7 days

    Blood cytokines

Sponsors and collaborators

Lead sponsor

Universidad Complutense de Madrid

Other

Registry information

Official study title

Cocktail of Vitamin B, Vitamin D and Melatonine VS Ibuprofen in the Surgical Third Molar Extraction. Randomized Clinical Trial

Acronym: CoctailRCT

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 21, 2025
Registry last updated
Aug 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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