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OpenTrials
Completed

NCT Number: NCT00367094

Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension

This study will evaluate efficacy and safety data for benazepril/hydrochlorothiazide in adult Chinese patients with mild to moderate essential hypertension. Patients whose blood pressure is not adequately controlled with benazepril monotherapy during a 4 week run-in period will be randomly allocated to double blind treatment over 8 weeks with either a combination of benazepril/hydrochlorothiazide per day or continuation of benazepril per day.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Novartis

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female patients, age 18 or older
  • Given informed consent
  • Diagnosed as having mild to moderate essential hypertension

Exclusion criteria

  • Severe hypertension
  • Significant preexisting cardiovascular and cerebrovascular disease
  • Diabetes mellitus type 1 or poorly controlled diabetes mellitus type II
  • Advanced renal impairment

Other protocol-defined inclusion/exclusion criteria may apply.

Treatment and study plan

Benazepril plus hydrochlorothiazide

Drug

Primary outcomes

  1. Change in diastolic blood pressure from baseline to week 8

Secondary outcomes

  1. Change in systolic blood pressure from baseline to week 8

  2. Proportion of patients with blood pressure less than 140/90 mmHg at week 8

  3. Ambulant blood pressure monitoring profiles at baseline and week 8

Sponsors and collaborators

Lead sponsor

Novartis

Industry

Registry information

Official study title

Efficacy and Safety of the Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension Not Adequately Controlled With Benazepril

Important dates

Study start
2006
First posted
Aug 22, 2006
Registry last updated
Jul 9, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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