Colorectal Polyp Resection Adequacy

The purpose of this study is to determine the best way to ensure that polyps are completely removed by evaluating the borders of the removed polyp. If a polyp is found that meets the size requirements for the study, the investigators will take extra biopsies of the margin to determine if there is any abnormal tissue or cancer at these borders.

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Key information

Conditions

Polyp Resection Adequacy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Polyps

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Rush University Medical Center

Chicago, Illinois, 60612, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 40-80

Exclusion criteria

Coagulopathy (international normalized ratio >2)
Inflammatory bowel disease or other active colitides
Polyps of index colonoscopy that were felt not to be completely resected or pedunculated
Familial adenomatous polyposis or hereditary polyposis
Potential hereditary cancer syndrome (Lynch Syndrome)

Treatment and study plan

Primary outcomes

The incomplete resection rates in polyps from Group 1 (clear margins) versus Group 2 (positive margins).

Time frame: Between 3-6 months

Define the frequency of free margins versus margins that have dysplasia to the cautery site in snare polypectomy. A free margin is defined as uninvolved or normal mucosa extending to the cautery margin at the polypectomy stalk.

Sponsors and collaborators

Lead sponsor

Rush University Medical Center

Other

Registry information

Official study title

Determining True Colorectal Polyp Resection Adequacy: Correlation of Endoscopic Margins With Histopathologic Margins

Important dates

Study start: 2014
Primary completion: 2022
Study completion: 2022
First posted: Aug 15, 2014
Registry last updated: Aug 23, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed