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NCT Number: NCT00898079

Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer

This study is collecting and storing malignant, borderline malignant neoplasms, and related biological samples from young patients with cancer. Collecting and storing samples of tumor tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help the study of cancer in the future.

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Key information

Conditions

Acute Undifferentiated Leukemia Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative Bone Marrow Diseases Childhood Acute Lymphoblastic Leukemia Childhood Acute Myeloid Leukemia Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive Childhood Solid Neoplasm Chronic Disease Chronic Lymphocytic Leukemia Disease Attributes Hairy Cell Leukemia Hematologic Diseases Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Juvenile Myelomonocytic Leukemia Leukemia Leukemia, B-Cell Leukemia, Biphenotypic, Acute Leukemia, Hairy Cell Leukemia, Large Granular Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Lymphoid Leukemia, Mast-Cell Leukemia, Myeloid Leukemia, Myeloid, Acute Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Leukemia, Myelomonocytic, Juvenile Leukemia, Prolymphocytic Leukemia, T-Cell Lymphatic Diseases Lymphoproliferative Disorders Mast Cell Activation Disorders Mast Cell Leukemia Mastocytosis Mastocytosis, Systemic Myelodysplastic-Myeloproliferative Diseases Neoplasm of Uncertain Malignant Potential Neoplasms Neoplasms by Histologic Type Pathologic Processes Pathological Conditions, Signs and Symptoms Precursor Cell Lymphoblastic Leukemia-Lymphoma Prolymphocytic Leukemia Secondary Acute Myeloid Leukemia T-cell Large Granular Lymphocyte Leukemia

Age range

Up to 30 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia, Australia

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About this study

OBJECTIVES:

I. Collect malignant, borderline malignant neoplasms, and related biological specimens from Children's Oncology Group institutions for cases in which there is no disease-specific biologic protocol.

II. Provide a repository for long-term storage of malignant, borderline malignant neoplasms, and related biological specimens from these patients.

III. Make specimens available to qualified researchers to understand the biology of cancer in these patients.

OUTLINE:

Tumor tissue samples, blood, and bone marrow aspirates are collected and stored for future analysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meets any of the following criteria:
  • Diagnosed with primary neoplasm
  • Developed a second malignant neoplasm
  • Any diagnoses having an ICD-O Morphology Code ending in 1, 2, or 3 as listed in the International Classification of Disease for Oncology, Third Edition
  • Must have biological specimens including solid tumors and leukemias available
  • Solid tumors meeting the following criteria:
  • Snap frozen primary tumor OR OCT embedded primary tumor OR formalin fixed (block or tissue in formalin) primary tumor AND at least 10 unstained paraffin slides for NIH Mandated QC (tumors that have undergone central pathology review are allowed)
  • Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
  • Pleural fluid or cytologic specimens meeting the following criteria:
  • At least 1 mL of fluid and at least 2 unstained cytospin slides (or 2 unstained smears)
  • Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
  • ALL/AML
  • 3-6 mL of bone marrow aspirate and 10 mL of whole blood
  • Not eligible for disease-specific biology or banking protocol

Treatment and study plan

Cytology Specimen Collection Procedure

Other

Correlative studies

Other names: Cytologic Sampling

Primary outcomes

  1. Repository of malignant, borderline malignant neoplasms, and related biological specimens

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Children's Oncology Group

Network

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors

Important dates

Study start
2003
Primary completion
2018
Study completion
2018
First posted
May 12, 2009
Registry last updated
Jul 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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