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OpenTrials
Completed

NCT Number: NCT02734563

Collagen Alterations in Patients With Abdominal Wall Hernias

The aim of this study was to evaluate collagen turnover in patients with multiple hernias

Completed

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Key information

Conditions

Hernia, Abdominal Hernia Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

Male

Study type

Observational

Primary location

Bispebjerg Hospital

Copenhagen, NV, DK-2400, Denmark

About this study

Venous blood was collected and markers for type IV and V collagen synthesis and breakdown was measured

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with a history of three hernia repairs (multiple hernia group)
  • patients without any history or presence of hernias (control group)

Exclusion criteria

  • connective tissue disorder (Ehlers-Danloss/Marfan)
  • presence of hernia upon clinical examination (control group)

Treatment and study plan

Collagen turnover

Other

Type IV and V collagen synthesis and breakdown

Primary outcomes

  1. Type IV and V collagen synthesis and breakdown

    Time frame: 3 months

    Products from type IV and V collagen synthesis and breakdown are measured in serum. with ELISA from Nordic Bioscience A/S, Herlev, Denmark. Specifically, the biomarker for type IV collagen synthesis (P4NP) and breakdown (C4M), and for type V collagen synthesis (P5CP) and breakdown (C5M) was measured. The concentration unit for all parameters is ng/ml.

Sponsors and collaborators

Lead sponsor

Bispebjerg Hospital

Other

Registry information

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Apr 12, 2016
Registry last updated
Jul 18, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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