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Completed

NCT Number: NCT07348770

Cold Plasma Effects on Dental Implant Stability

Cold plasma-mediated implant surface activation may reverse the biological aging of titanium by enhancing hydrophilicity and cellular response. The aim of this study was to clinically compare the effects of three different cold plasma systems on the stability of dental implants. In this prospective randomized controlled within-patient trial, a total of 44 implants were placed in 11 patients. In each patient, four implants were randomly allocated to one of the following groups: control, vacuum plasma, argon jet plasma, and cold atmospheric plasma. All implants were placed using a single-stage protocol with a minimum insertion torque of 45 Ncm. Implant stability was assessed using resonance frequency analysis (ISQ values) immediately after placement and at 2, 4, and 8 weeks.

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Key information

Conditions

Cold Atmospheric Plasma Dental Implants

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kahramanmaras Sutcu Imam University, Faculty of Dentistry

Kahramanmaraş, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years.
  • Presence of edentulous areas requiring ≥4 implants for fixed prosthetic rehabilitation.
  • Good or moderate oral hygiene.
  • Adequate patient compliance to attend all follow-up appointments.
  • Willingness to voluntarily participate in the study.

Exclusion criteria

  • Refusal to participate.
  • Need for alveolar ridge augmentation.
  • Systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunodeficiency, ongoing chemotherapy or radiotherapy, history of head-and-neck radiotherapy, substance or alcohol abuse).
  • Untreated periodontal disease.
  • Heavy smoking (>10 cigarettes/day).
  • Age < 18 years.

Treatment and study plan

Dental implant placement

Procedure

The dental implant was placed without any plasma application.

Dental implant placement and vacuum plasma application

Procedure

The dental implant was placed with non-thermal low-pressure cold plasma application

Dental implant placement and argon jet plasma application

Procedure

The dental implant was placed with argon jet plasma application

Dental implant placement and cold atmospheric plasma application

Procedure

The dental implant was placed with cold atmospheric plasma application

Primary outcomes

  1. Evaluation of Implant Stability

    Time frame: Measurements were performed at four different time points: • Immediately after placement (baseline), • 2 weeks, • 4 weeks, • 8 weeks.

    The primary outcome measure was implant stability, quantified using Implant Stability Quotient (ISQ) values obtained by resonance frequency analysis (RFA). Changes in mean ISQ values were assessed at four predefined time points across four different implant surface treatment groups.

    The secondary outcome measure was the early stability pattern, evaluated based on serial ISQ measurements recorded during the first 8 weeks following implant placement.

Sponsors and collaborators

Lead sponsor

Kahramanmaras Sutcu Imam University

Other

Registry information

Official study title

Clinical Evaluation of Cold Plasma Surface Activation Using Different Plasma Systems on Early Implant Stability: A Randomized Controlled Within-Patient Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 16, 2026
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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