Cohort Study of the Patterns of Microvesicles in the Serum of Participants With Atopic and Non-atopic Asthma

A total of 20 participants (men or women) between the ages of 18-50 years with asthma will be enrolled. Participants will remain on their usual asthma treatments as prescribed by their usual asthma care provider. Current asthma treatments and any changes will be recorded at baseline and each subsequent visit. The primary outcome measures are correlation of microvesicle patterns with atopic state and variation from baseline with episodes of poor asthma control. Secondary outcomes include correlations between microvesicle patterns and spirometry, eNO levels, and glucorcorticoid sensitivity.

Inclusion criteria

• be between the ages of 18 and 50.
• have diagnosed asthma.
• must have less "one pack per day for 10 years" smoking history

Exclusion criteria

• You have had a fever of 100.4º within 24 hours of Visit 2.
• You are enrolled in another interventional research trial.
• Have other major chronic illnesses that would interfere with participation in the study.
• You are pregnant.
• You chronically use oral corticosteroids.
• You have taken anti-coagulants, insulin, and any investigative drugs within 2 months.
• You have the inability or unwillingness to provide consent.
• Inability to perform aerobic exercise.
• Inability to perform baseline measurements.
• Less than 80% completion of screening period diaries.
• Inability to be contacted by telephone.
• Intention to move out of the area within 6 months.