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Completed

NCT Number: NCT02301546

Cognitive Training and Practice Effects in Mild Cognitive Impairment

The current study will test the effectiveness of a computerized cognitive training program on auditory memory and attention in patients with mild cognitive impairment. Practice effects will also be examined as a moderator of treatment response.

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Utah Center for Alzheimer's Care, Imaging and Research

Salt Lake City, Utah, 84108, United States

About this study

The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Mild Cognitive Impairment, amnestic subtype
  • 65 years of age or older
  • Availability of a knowledgeable informant
  • Access to internet 3 hours per week
  • Adequate vision, hearing, and motor responding to participate in training

Exclusion criteria

  • History of major stroke, head injury with loss of consciousness of >30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)
  • Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)
  • History of substance abuse
  • Current use of antipsychotics or anticonvulsant medications
  • Currently residing in a nursing home or other skilled nursing facility

Treatment and study plan

computerized cognitive exercises

Behavioral

Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

Primary outcomes

  1. Auditory Memory Attention Index

    Time frame: 13 weeks

    This is a composite of six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status. It is a standard score (mean=100, standard deviation=15), with a range of approximately 45 - 145, with higher scores indicating better outcome.

Sponsors and collaborators

Lead sponsor

University of Utah

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Important dates

Study start
2015
Primary completion
2020
Study completion
2020
First posted
Nov 26, 2014
Registry last updated
Jun 9, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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