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OpenTrials
Completed

NCT Number: NCT01271413

Cognitive Stimulation

This research is being done to learn if computer tasks that challenge the brain (cognitively stimulating tasks) can improve memory and other types of thinking. The study will compare the effects of different versions of the computer tasks. It also will compare the task performance of different groups of people.

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Key information

Conditions

Substance Use Disorders Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

BPRU, Johns Hopkins Bayview Medical Center

Baltimore, Maryland, 21224, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18-55
  • in methadone maintenance or healthy volunteers
  • healthy

Exclusion criteria

  • Axis I disorder (except substance abuse and dependence in methadone maintenance patients)
  • severe cognitive impairment
  • serious untreated medical condition

Treatment and study plan

Computerized cognitively stimulating activities

Behavioral

The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.

Primary outcomes

  1. Working Memory

    Time frame: baseline, 7 weeks

    Change in maximum number of digits correctly recalled in Digit Span Backwards task, from baseline to 7 weeks

Secondary outcomes

  1. Episodic Memory

    Time frame: baseline, 7 weeks

  2. Trail-making

    Time frame: baseline, 7 weeks

  3. go/No-go

    Time frame: baseline, 7 weeks

  4. Addiction Severity Index

    Time frame: baseline, 7 weeks

  5. Delay Discounting

    Time frame: baseline, 7 weeks

  6. Digit Symbol Substitution Test

    Time frame: baseline, 7 weeks

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effects of Cognitive Training in Methadone Maintenance Patients

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Jan 6, 2011
Registry last updated
Apr 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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