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OpenTrials
Completed

NCT Number: NCT01393457

Cognitive Remediation for Cocaine Dependence

The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.

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Key information

Conditions

Cocaine Dependence Chemically-Induced Disorders Cocaine-Related Disorders Mental Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Behavioral and Biomedical Sciences Building

Houston, Texas, 77045, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • meet criteria for cocaine dependence
  • seeking treatment for cocaine dependence
  • be in acceptable health based on medical history and physical exam

Exclusion criteria

  • dependent on drugs other than cocaine, nicotine, marijuana
  • have a medical condition contraindicating treatment with study medications
  • having conditions of probation or parole requiring reports of drug use to officers of the court

Treatment and study plan

Levodopa/carbidopa

Drug

800/200 mg/d

Other names: ldopa

Ropinirole 2 mg/d

Drug

2 mg/d

Other names: Requip

Placebo

Drug

sugar pill

Ropinirole 4 mg/d

Drug

4 mg/d

Other names: Requip

Primary outcomes

  1. Cocaine Use Based on Urine Drug Screening

    Time frame: 10 weeks

    The mean of the predicted probabilities (derived from generalized linear mixed models) of negative drug screens over all 10 weeks is reported, as per the analysis proposed in the protocol.

Secondary outcomes

  1. Number of Participants Who Completed the 10 Week Trial

    Time frame: 10 weeks

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Registry information

Official study title

Cognitive-enhancing DA Medications for Cocaine Dependence

Important dates

Study start
2011
Primary completion
2017
Study completion
2017
First posted
Jul 13, 2011
Registry last updated
Mar 29, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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