King's College London
London, SE5, United Kingdom
NCT Number: NCT06989151
Autistic youth have extremely high levels of co-occurring mental health difficulties, including rates of depression and anxiety which are between two and four times more common compered to non-autistic people. Cognitive inflexibility is a characteristic which is strongly associated with higher levels of anxiety and depression in autism. Currently, there are no existing treatments which can promote flexible thinking. Cognitive Remediation Therapy is a promising intervention which has been used with different patient groups to improve flexibility. This study aims to develop and adapt the current CRT treatment for use with autistic youth and then conduct a pilot study with 20 participants.
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Notify Me12 year–16 year
All sexes
Interventional
Early Phase 1
London, SE5, United Kingdom
The existing evidence that CRT is effective for those with autistic features leads us to hypothesize that with minor adaptations the intervention will be acceptable to those with autism. Given the strong association between CI and anxiety (and other internalizing difficulties such as depression; ref) by targeting this specific trait it is hypothesized that an adapted CRT will a) increase flexible thinking and b) reduce symptoms of anxiety and depression.
Key objectives:
Methods:
Participants will all complete 8 adapted CRT intervention sessions held twice weekly. Outcome measures will be collected pre- and post intervention. Measures of acceptability of the intervention (e.g., retention rate) will be recorded and qualitative interviews will gather feedback on the intervention.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
8 session psychological intervention.
Time frame: 8 weeks
Number of participants who drop-out from the study
Time frame: 8 weeks
total number of sessions attended out of a maximum of 8 per participant
Time frame: 8 weeks
Completion rates of between session work - recorded as percentage.
Time frame: 8 weeks
Time frame: 8 weeks
Questionnaire measure of flexibility
Time frame: 8 weeks
Detail and Flexibility Questionnaire
Time frame: 8 weeks
Time frame: 8 weeks
Time frame: 8 weeks
South London and Maudsley NHS Foundation Trust
Other
A Pilot Study of Cognitive Remediation Therapy for Autistic Adolescents
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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