COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old

Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

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Key information

Conditions

Memory Impairment Acquired Immunodeficiency Syndrome Blood-Borne Infections Cognition Disorders Cognitive Dysfunction Cognitive Impairment Communicable Diseases Genital Diseases HIV Infections HIV/AIDS Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Memory Disorders Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Signs and Symptoms Slow Virus Diseases Urogenital Diseases Virus Diseases

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation Ophtalmologique A. de Rothschild /URC

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Personal or familial cognitive complaints
Individual aged ≥ 65 years old and < 81 years old
Instrumental activities of daily living (IADL) score between 3-4
French speaking individual
Informed consent signed For PLHIV
HIV infection
Undetectable HIV viral load ≥ 1 year
Current cluster of differentiation (CD4) cell count > 100/mm3 For controls
negative HIV serology ≤ 6 months

Exclusion criteria

Opportunistic infection < 5 years
Contraindications to MRI

Treatment and study plan

assessment of cognitive impairment

Other

Measure of Global Deficit Score

Primary outcomes

cognitive impairment

Time frame: baseline

cognitive impairment frequency, defined by a z-score ≤ 1.65 in at least 2 cognitive domains

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Official study title

COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old.

Acronym: COGITO

Important dates

Study start: 2017
Primary completion: 2025
Study completion: 2025
First posted: Aug 31, 2017
Registry last updated: Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed