Skip to main content
OpenTrials
Completed

NCT Number: NCT04978246

Cognitive Functions After COVID-19

This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. 50 individuals with COVID-19 and 50 healthy control groups were included in the study. Cognitive functions of individuals with COVID19 compared with healthy individuals.

Completed

Looking for future studies?

Notify Me

Key information

About this study

This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. Fifty COVID-19 patients, aged between 18-50 years, who had positive RT-PCR test in the last 60 days and later recovered, were included in the study. The study group was compared with the control group consisting of 50 healthy individuals in whom gender, age and education year has not difference significantly. Participants' global cognitive skills were measured by the Montreal Cognitive Assessment Test (MoCA), the Clock Drawing Test and memory functions, the Öktem Verbal Memory Processes Test (Ö-SBST), the attention functions by the Digit Span Forward and Digit Span Backwards Test, the executive functions by Categorical Fluency, Phonemic Fluency, the Stroop Test, Trail Making Test A and B, visuospatial skills were evaluated with the Rey-Osterrieth Complex Figure Test (ROCF), and behavioral symptoms were evaluated with the Neuropsychiatric Inventory (NPI). The study group was evaluated between 21 and 60 days from the onset of the disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having positive for the COVID-19 RT-PCR test and turned negative in the last 60 days.
  • be 18-50 years old
  • 21 days have passed since the onset of the disease

Exclusion criteria

  • Having any neurological or psychiatric illness

Treatment and study plan

Neuropsychometric Test

Behavioral

Participants' global cognitive skills were measured by the Montreal Cognitive Assessment Test (MoCA), the Clock Drawing Test and memory functions, the Öktem Verbal Memory Processes Test (Ö-SBST), the attention functions by the Digit Span Forward and Digit Span Backwards Test, the executive functions by Categorical Fluency, Phonemic Fluency, the Stroop Test, Trail Making Test A and B, visuospatial skills were evaluated with the Rey-Osterrieth Complex Figure Test (ROCF), and behavioral symptoms were evaluated with the Neuropsychiatric Inventory (NPI).

Other names: Montreal Cognitive Assessment Test (MoCA), Clock Drawing Test, Öktem Verbal Memory Processes Test (Ö-SBST), Digit Span Forward Test, Digit Span Backwards Test, Categorical Fluency, Phonemic Fluency, Stroop Test, Trail Making Test A, Trail Making Test B, Rey-Osterrieth Complex Figure Test (ROCF), Neuropsychiatric Inventory (NPI)

Primary outcomes

  1. Montreal Cognitive Assessment Test (MoCA)

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    It is a test that measures attention and concentration, executive functions, memory, language, visuospatial skills, abstract thinking, calculation and orientation skills in order to distinguish individuals with mild cognitive impairment from healthy individuals.

Secondary outcomes

  1. Clock Drawing Test

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The person is asked to draw a clock circle and place numbers in it. After succeeding, they are asked to show 11 by 10 crossing. This test can test comprehension, memory, visuospatial functions and executive functions.

  2. Öktem Verbal Memory Processes Test (Ö-SBST)

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The test consists of fifteen unrelated words. Fifteen words are read to the subject at one-second intervals and then asked to say the ones that come to mind. In this process, information is collected about the subject's ability to maintain instant memory and attention. The number of correct answers of the subject is recorded as Instant Memory Score. After the first attempt, the same list is read to the subject nine more times, and each time he is asked to say all he remembers. This gives information about the subject's learning ability.

  3. Digit Span

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The test consists of two parts as forward and backward span. In the forward digit span, the numbers are read at one second intervals and the patient is asked to repeat the randomly read numbers in the same order. It assesses attention and short-term memory. In the back digit span, it is requested to repeat the numbers read from the end to the beginning. Working memory is evaluated in the back count range. As the person succeeds in the trials, the test is continued by increasing one step. If the patient fails twice in a row for both sections, the test is discontinued.

  4. Verbal Fluency Test

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    Verbal fluency tests aim to evaluate the executive aspects of verbal behavior by using language capacity as a fluent speech. Verbal fluency tests are applied in two ways: phonemic fluency and semantic fluency. In the semantic fluency test, the person is asked to count animal names in one minute, and in the phonemic fluency test, the person is asked to produce words that start with a certain letter (K-A-S) and are not proper nouns.

  5. Stroop Test

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The Stroop test evaluates focused attention, the ability to change attention in line with changing demands and under a distraction, the ability to suppress a habitual behavior pattern and perform an unusual behavior.

  6. Trail Making Test

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The trail making test consists of two parts, A and B. In part A, the participants are asked to combine the circles with the numbers in the correct order and following each other (1-2-3-4-5...). In section B, there are letters and numbers placed in circles. Participants are asked to combine letters and numbers in the correct sequence (1-A-2-B-3-C-4-D...). The times of both sections are recorded. The A part of the IST evaluates the processing speed based on visual scanning ability, and the B part evaluates the complex attention, planning, set changing, blocking ability and following the sequentiality.

  7. Rey-Osterrieth Complex Figure Test (ROCF)

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The purpose of the test is to evaluate visuospatial structuring skills and visual memory. The test material consists of a complex shape printed on a card, a registration form, an identification form with 24 details, three blank sheets of paper, a pencil and an eraser. The subject is first asked to copy the complex shape and the copying time is noted. During copying, the subject is not informed that he will draw the shape again. In the next step, the complex shape is removed and the person is asked to draw the shape again as far as he can remember, and the drawing time is noted. This is instant recall application. After the instant recall, the subject is not informed that he will draw the shape again, and the subject's mind is occupied by introducing different tests. After 30 minutes, he is asked to draw again. This is the delayed recall phase.

  8. Neuropsychiatric Inventory (NPI)

    Time frame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.

    The scale is scored by interview with the patient's relative. A total of 12 behavioral domains (delusions, hallucinations, agitation/aggression, depression/dysphoria, anxiety, elation/euphoria, apathy, disinhibition, irritability/lability, abnormal motor behavior, sleep/night behaviors, appetite and eating changes) are questioned.

Sponsors and collaborators

Lead sponsor

Medipol University

Other

Registry information

Official study title

Evaluation Of Cognitive Functions In Adult Individuals With COVID-19

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jul 27, 2021
Registry last updated
Aug 5, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.