Skip to main content
OpenTrials
Completed

NCT Number: NCT07184073

Cognitive Fraility and Biomarkers in Older Patients

this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery.

The main questions it aims to answer is:

* Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cognitive Impairment Charcot-Marie-Tooth disease, Type 1F Cognition Disorders Cognitive Dysfunction Frail Older Adults Mental Disorders Neurocognitive Disorders Orthopaedic Surgery

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Baskent University Ankara Hospital

Ankara, Turkey (Türkiye)

About this study

It is a cross sectional study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 1-3 patients
  • >65 age patients

Exclusion criteria

  • history of psychiatric or neurological disease
  • uncontrolled hypertension
  • alchohol dependence
  • renal failure
  • active liver disease
  • cancer-related or emergency surgery
  • unwillingness to participate

Treatment and study plan

assessment Mini mental state examination

Behavioral

pre operatively four weeks postoperatively

assessment FRAIL scale

Behavioral

pre operatively four weeks postoperatively

collecting cerebrospinal fluid during regional anesthesia

Other

In the operating room regional anesthesia was administered according to the surgical plan

Primary outcomes

  1. Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?

    Time frame: preoperatively and four weeks postoperatively

    p<0,05 was accepted as statistically significant

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Official study title

Association Between Cognitive Fraility and Blood and CSF Biomarkers in Older Orthopedic Patients Under Regional Anesthesia

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 19, 2025
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.