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Completed

NCT Number: NCT03094520

Cognitive Embodiment Activation by tDCS

The main objective of the proposed research is to extend our understanding of how gesture and language interact, focusing on the role of cognitive embodiment in this interaction, and to explore the neural systems that support links between language and actions systems.

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Key information

Conditions

Healthy Young Adults

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Charité

Berlin, 10117, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Right handedness
  • unobtrusive neuropsychological screening

Exclusion criteria

  • History of severe alcoholism or use of drugs.
  • Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
  • Contraindication for MRT (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).

Treatment and study plan

tDCS

Device

Transcranial direct current stimulation (tDCS)

Other names: Neuroconn

sham-tDCS

Device

sham stimulation

Other names: Neuroconn

Primary outcomes

  1. response time in semantic decision task

    Time frame: assessed during stimulation or sham stimulation of semantic decision task (last approximately 10 min) at specific timepoint within 2 weeks

    Comparing response time in semantic decision task under anodal tDCS compared to sham stimulation (change from sham stimulation)

  2. performance in attentional load task

    Time frame: assessed during stimulation or sham stimulation of attentional load task (last approximately 6 min) at specific timepoint within 2 weeks

    Attentional load task: Participants are presented with a 6 positions ring that includes different shapes, they have to press V when they see a square and N when they see a diamond. They will have to ignore any shapes other than square and diamond within the ring or distractors that appear outside the ring.

    Comparing performance in attentional load task under anodal tDCS compared to sham stimulation (change from sham stimulation)

  3. performance in motor task

    Time frame: assessed during stimulation or sham stimulation of motor task (last approximately 4 min) at specific timepoint within 2 weeks

    Motor Task: Participants are presented with a red Box and they have to click a button each time they see it as fast as they can.

    Comparing performance in motor task under anodal tDCS compared to sham stimulation (change from sham stimulation)

Secondary outcomes

  1. Functional connectivity predictors

    Time frame: assessed during baseline testing

    Connectivity as measured by resting-state fMRI during baseline as predictors for performance and tDCS responsiveness

  2. Other cognitive outcomes: change in working memory performance

    Time frame: change in working memory performance from baseline after 30 min (approximately)

    Digit span backward performance assessed before (baseline) and after stimulation to test for tDCS effects on working memory

  3. Other cognitive outcomes: change in Attention performance

    Time frame: change in attention performance from baseline after 30 min (approximately)

    Digit span forward performance assessed before baseline) and after stimulation to test for tDCS effects on attention

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Registry information

Official study title

Effects of Transcranial Direct Current Stimulation (tDCS) on Gestural-verbal Brain Associations: the Role of Cognitive Embodiment

Acronym: GEST

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Mar 29, 2017
Registry last updated
May 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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