Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression

Inclusion criteria

• Study population: depressed subjects treated with ECT

• Male or female over 18 years of age
• Hospitalised at the Centre Hospitalier Sainte-Anne
• Suffering from a unipolar or bipolar major depressive episode, according to DSM5 criteria
• Indication for ECT treatment
• Patient has given informed written consent
• Beneficiary of a social security scheme
• Control population: depressed subjects treated without ECT

• Male or female over 18 years of age
• Hospitalised at the Centre Hospitalier Sainte-Anne
• Suffering from a unipolar or bipolar major depressive episode, according to DSM5 criteria
• Patient who has given informed written consent
• Beneficiary of a social security scheme
• Control population: healthy volunteers

• Male or female over 18 years of age
• Patient with written informed consent
• Beneficiary of a social security scheme

Exclusion criteria

• Study population: depressed subjects with ECT

• Psychiatric comorbidity: schizophrenia, pervasive developmental disorder, dependence on a substance other than tobacco
• Neurological comorbidity: Parkinson's disease, dementia
• ECT treatment in the 6 months prior to inclusion
• Compulsory care
• Protected adults, persons under court protection measures
• Persons deprived of liberty by judicial or administrative decision;
• Refusal of consent to ECT treatment
• Contraindications to ECT (HTIC, recent history of stroke, severe uncontrolled arterial hypertension, contraindication to anaesthesia)
• Contraindications to MRI (patients with metal prostheses, claustrophobia)
• Pregnant or breast-feeding women
• Control population: depressed subjects without ECT

• Psychiatric comorbidity: schizophrenia, pervasive developmental disorder, dependence on any substance other than tobacco
• Neurological comorbidity: Parkinson's disease, dementia
• ECT treatment in the 6 months prior to inclusion
• Compulsory care
• Protected adults, persons under court protection measures
• Persons deprived of liberty by judicial or administrative decision;
• Pregnant or breast-feeding women
• Control population: healthyvolunteers

• Protected adults, persons under legal protection,
• Persons deprived of their liberty by judicial or administrative decision ;
• persons hospitalised for purposes other than research
• Clear psychiatric history
• Dependence on any substance other than tobacco
• Neurological history: Parkinson's disease, dementia
• Pregnant or breast-feeding women