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Completed

NCT Number: NCT01038193

Cognitive Dysfunction After Aneurysmal Subarachnoid Haemorrhage

This is a longitudinal, multi-center, prospective study of aneurysmal subarachnoid haemorrhage patients in neurosurgical units in Hong Kong.

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Key information

Conditions

Cognitive Dysfunction Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Cognition Disorders Hemorrhage Intracranial Hemorrhages Mental Disorders Nervous System Diseases Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Subarachnoid Hemorrhage Vascular Diseases

Age range

21 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Prince of Wales Hospital

Hong Kong, 852, China

About this study

The investigators aim to recruit a total of 240 aneurysmal subarachnoid haemorrhage patients. The schedule for neuropsychological and functional assessments will be phased in at the second to third week, the third month, and the twelve months after the initial haemorrhage.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Spontaneous subarachnoid haemorrhage with intracranial aneurysms as aetiology
  • Admission within 96 hours of ictus
  • Aged between 21 and 75 years
  • A speaker of Chinese (Mandarin or Cantonese)
  • Informed consent from patients or their legally acceptable representatives

Exclusion criteria

  • History of previous cerebrovascular disease or neurological disease other than intracranial aneurysm
  • History of neurosurgical operation prior to ictus

Treatment and study plan

Cognitive Assessment

Other

Cognitive and functional assessments at 2-4 weeks, 3 months and 12 months.

Other names: Cognition

Primary outcomes

  1. Cognitive dysfunction

    Time frame: 3 and 12 months

    Montreal Cognitive Assessment

Secondary outcomes

  1. Neurological Outcome

    Time frame: 3 and 12 months

    Modified Rankin Scale

  2. Generic Quality of Life

    Time frame: 3 and 12 months

    ShortForm36(SF-36)

  3. Activity of Daily Living

    Time frame: 3 and 12 months

    Barthel Index

  4. Disease-specific Quality of Life

    Time frame: 3 and 12 months

    Stroke-specific-QOL

  5. Functional Outcome

    Time frame: 3 and 12 months

    Functional Independent Measure (FIM)

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Important dates

Study start
2009
Primary completion
2023
Study completion
2023
First posted
Dec 23, 2009
Registry last updated
Feb 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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