Skip to main content
OpenTrials
Completed

NCT Number: NCT02407652

Cognitive Control Training for Remitted Depressed Patients

The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.

Completed

Looking for future studies?

Notify Me

Key information

Age range

23 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ghent University

Ghent, Oost-Vlaanderen, 9000, Belgium

About this study

Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of ≥ 1 depressive episode(s)
  • Currently in stable full or partial remission (≥ 6 months)

Exclusion criteria

  • Major depressive disorder (MDD; current)
  • Bipolar disorder (current and/or previous)
  • Psychotic disorder (current and/or previous)
  • Neurological impairments (current and/or previous)
  • Excessive substance abuse (current and/or previous)
  • No other comorbid disorders (current)
  • No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks)
  • Use of antidepressant medication is allowed if kept at a constant level

Treatment and study plan

Cognitive Control Training

Behavioral

10 adaptive Paced Auditory Serial Addition Task (PASAT) sessions, 400 trials each

Low Cognitive Load Training

Behavioral

10 low cognitive load sessions, 400 trials each

Primary outcomes

  1. Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)

    Time frame: baseline, 2 weeks, 3 months

    Assessed using the Ruminative Response Scale (RRS)

  2. Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II)

    Time frame: baseline, 2 weeks, 3 months

    Assessed using the Beck Depression Inventory (BDI-II)

Secondary outcomes

  1. (mal-)Adaptive cognitive emotion regulation (CERQ)

    Time frame: baseline, 2 weeks, 3 months

    Assessed using the Cognitive Emotion Regulation Questionnaire (CERQ)

  2. Quality of Life (QLDS)

    Time frame: baseline, 3 months

    Assessed using the Quality of Life in Depression Scale (QLDS)

  3. Disability (WHODAS 2.0)

    Time frame: baseline, 3 months

    Assessed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)

  4. Resilience (RS)

    Time frame: baseline, 3 months

    Assessed using the Resilience Scale (RS)

  5. Remission from depression (RDQ)

    Time frame: baseline, 3 months

    Assessed using the Remission of Depression Questionnaire (RDQ)

Other outcomes

  1. Behavioral measure for cognitive control ((non-adaptive) PASAT)

    Time frame: baseline, 2 weeks, 3 months

    Assessed using the (non-adaptive) PASAT

  2. Self-reported cognitive control (BRIEF-A)

    Time frame: baseline, 2 weeks, 3 months

    Assessed using the Behaviour Rating Inventory of Executive Function Adult Version (BRIEF-A)

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Registry information

Official study title

Cognitive Control Training as a Preventive Intervention for Depression: A Double-blind Randomized Controlled Trial Study

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Apr 3, 2015
Registry last updated
Dec 17, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.