Cognitive and Psychological Disorders After Severe COVID-19 Infection

Initial consecutive screening of patients (<65 years) hospitalized between the 01/10/2020 and the 01/07/2021 for more than 72 hours for COVID-19 infection in 6 hospitals of the East of France. If detection of cognitive complaints (QPC scale : Questionnaire of cognitive complaints), continuation of the study.

Evaluation with cognitive assessments, morphological and functional imaging and EEG will be done at 9 ± 3 months and 2 years after initial hospitalisation. Data will be collected concerning social and professional outcome.

An ancillary study will be conducted at the Nancy University Hospital. This ancillary study is entitled "TRAUMA-COV: Screening and therapeutic proposal of post-traumatic sequelae in the aftermath of a severe Covid-19 in young subjects". The main objective of this study is to evaluate the incidence of post-Covid-19 post-traumatic disorders (post-traumatic stress disorder, psychogenic and somatoform dissociative tendency, neurological dissociative disorder) in a longitudinal way. This optional study will be offered to all patients from the main study who meet the selection criteria.

Inclusion criteria

• Patients between 18 and 65 years of age (at discharge of hospitalization),
• Patient hospitalized for more than 72 hours (in intensive care or conventional sector) for a COVID-19 infection defined by a positive PCR (Polymerase Chain Reaction) test and/or typical aspect on thoracic scanner,
• Patient discharged from hospital between 01/10/2020 and 01/04/2021,
• Patient with suspected cognitive impairment (obtaining a pathologic QPC score) during the phone screening,
• Patient having received complete information on the organization of the research and having given written informed consent (or a third person, independent of the investigator and the sponsor, in case of inability to read or write),
• Patient affiliated with a social security plan or beneficiary of such a plan,
• Patient with a sufficient level of written French comprehension to complete the cognitive assessment.

Exclusion criteria

• Inability to travel to perform the BNP or additional tests,
• Contraindication to perform brain MRI (pacemaker, etc.),
• Presence of chronic neurological diseases (multiple sclerosis, neurodegenerative disease, epilepsy) and/or major cognitive disorders (stroke, head trauma) pre-COVID-19,
• Presence of psychiatric disorder historys (bipolar or psychotic illness) pre-COVID-19,
• Patients with very extensive post-COVID-19 brain damage leading to impossibility to realise cognitive assessment,
• Addictive history or comorbidities (alcoholism, drug use) with sequelae of cognitive impairment,
• Persons covered by articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code.