Cognitive and Emotional Impairment After Stroke

Cognitive and emotional symptoms are often seen in the acute phase of a stroke. The prevalence of such symptoms later and the mechanisms explaining the symptoms are not fully known. The causes of poststroke dementia are likely to be multifactorial (Cerebrovascular Diseases 2006). The investigators want to include all patients with first ever stroke without significant cognitive decline prior to the stroke (IQCODE cut-off 3,7) and follow them up for one year. At baseline we will make stroke classifications, measure neurological deficits according to NIHSS, evaluate cognitive and emotional function and make registrations of vascular risk factors, including precerebral color duplex scan with measurement of IMT in CCA. The investigators will then randomize the patients into multifactorial vascular-risk-factor-intervention in the hospital or care as usual in the primary health care. 8-12 months after stroke onset, survivors will undergo new examinations to evaluate neurological, cognitive and emotional functions, as well as MRI and SPECT.

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Key information

Conditions

Stroke Arterial Occlusive Diseases Arteriosclerosis Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Cognition Disorders Cognitive Dysfunction Cognitive Impairment Dementia Dementia, Vascular Intracranial Arterial Diseases Intracranial Arteriosclerosis Leukoencephalopathies Mental Disorders Nervous System Diseases Neurocognitive Disorders Vascular Dementia Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sykehuset Asker og Baerum HF

Pb 83, 1309, RUD, Norway

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

First ever stroke or TIA
No cognitive decline (IQCODE < 3,7)
Survived the acute stroke
Expected to live at least for one year after stroke

Exclusion criteria

Cognitive decline

Treatment and study plan

Multifactorial vascular-risk-factor-intervention

Other

Primary outcomes

Effects of vascular risk-factor-intervention on changes in TMTA, ten-words-test and HAD

Time frame: 8-12 months after stroke onset

Secondary outcomes

Prevalence of dementia and depression after stroke

Time frame: 8-12 month after stroke onset

Sponsors and collaborators

Lead sponsor

Sykehuset Asker og Baerum

Other

Collaborators

University of Oslo

Registry information

Important dates

Study start: 2007
Primary completion: 2009
Study completion: 2009
First posted: Jul 25, 2007
Registry last updated: Sep 21, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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