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Completed

NCT Number: NCT02874482

Cognitive and Emotional Factors in Visual Exploration Among Patients With Schizophrenia

Background:

Patients with schizophrenia are abnormally disturbed by information onsets, which may result in a disadvantage in filtering relevant information. It seems that they accord the same importance to all objects in a scene without taking into account the relevance of objects (cognitive salience) or their emotional charge (salience emotional).

The paradigm of change blindness offers the interesting possibility of studying sensitivity to the sudden irruption of visual information with ecological stimuli in schizophrenia. An increased attentional capture by the irruption of visual information would suggest better performance in patients than in healthy controls. Moreover, patients are disturbed to processing of emotional information, in this way we would like to measure the impact of emotional salience on the visual exploration.

Main aim:

The main objective is to evaluate, if patients with schizophrenia quickly detect changes occurring on irrelevant objects in the understanding of the scene.

Secondary objectives:

To evaluate in patients with schizophrenia the impact of emotional salience using the same paradigm.

To separate an explicit response (motors responses) with an implicit response (eye tracking measures).

Methodology:

30 patients with schizophrenia and 30 healthy controls were asked to detect changes in 96 scenes with 0 or 1 change (neutral or emotional changes). We will measure the participants' speed and accuracy in explicitly reporting the changes via motor responses and their capacity to implicitly detect changes via eye movements.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital, Lille

Lille, 59037, France

About this study

This study will include one visit:

  • Written consent will be obtained from all participants
  • Inclusion and exclusion criteria will be checked
  • An ophthalmologic test, a pregnancy test, a alcohol test and a salivary test will be realized
  • Various symptoms will be assessed with the PANSS (Positive And Negative Syndrome Scale for schizophrenia) and the UPDRS (Unified Parkinson Disease Rating Scale for patients, the MOCA (Montreal Cognitive Assessment), The HAD (Hospital Anxiety and Depression Scale) and the MINI (Mini International Neuropsychiatric Interview) for all participants.
  • The task will be divided in two parts:

A visuo-spatial task allowing to record saccadic eye movements (approximately 10 min).

The change blindness session lasted approximately 20 min.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal or corrected vision
  • Affiliate to a social security system
  • For group of patients with schizophrenia : diagnosis of schizophrenia based on the standard DSM-IV criteria and patients will be clinically stable at the testing time

Exclusion criteria

  • History of neurological illness
  • Pregnant and nursing women
  • Drugs use in the last 24 hours
  • Acute ocular disorder
  • Under tutorship, curatorship or deprived of liberty
  • For controls group : be free DSM-IV axis-I diagnoses according the MINI test.

Treatment and study plan

Primary outcomes

  1. response time

    Time frame: 42 months

    The explicit response of the participants will be measure behaviourally by response time before the detection of neutral stimuli.

Secondary outcomes

  1. sensitivity index

    Time frame: 42 months

    Performances will be measure by a sensitivity index (D prime) which considers the number of correct detections compared with the missed detections and false alarms; thus it evaluates the capacity to discriminate the signal against a background noise.

  2. implicit response

    Time frame: 42 months

    The implicit response will be measure by the localization and duration of fixations

  3. emotional response

    Time frame: 42 months

    The emotional response will be measure by the localization, duration of fixations and performances for the detection of emotional stimuli

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Study of Cognitive and Emotional Factors Influencing the Visual Exploration Among Patients With Schizophrenia

Acronym: SAILLANCE1

Important dates

Study start
2014
Primary completion
2019
Study completion
2019
First posted
Aug 22, 2016
Registry last updated
Aug 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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