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OpenTrials
Completed

NCT Number: NCT04179435

Cognitive and Brain Development in Adolescents With Gilles de la Tourette Syndrome

In children with neurodevelopmental disorders, adolescence is usually associated with a reshaping of the clinical picture and symptomatology. Tourette syndrome (TS) is a paradigmal neurodevelopmental syndrome characterised by involuntary paroxysmal movements (motor tics) and vocalisation (vocal tics) often associated with various psychiatric disorders. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this study.

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Key information

Conditions

Tourette Syndrome in Adolescence

Age range

13 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital de la Pitié-Salpêtrière

Paris, 75013, France

About this study

Thus, the aims of the present project is threefold:

Aim 1: To evaluate the maturation of cognitive functions in adolescents with TS compared to typically developing adolescents.

To achieve this aim, three distinct cognitive dimensions will be assessed in all subjects (patients and controls): (i) reward sensitivity and habit formation; (ii) cognitive impulsivity and action control and (iii) self-agency.

Aim 2: To identify neuronal correlates of cognitive function and brain development in health and disease. To achieve this aim, we will use a combined behavioural (as described in Aim 1), (i) neuroimaging and (ii) TMS approaches.

Aim 3: To predict clinical outcome . In this part of the project we aim to identify behavioural, imaging or neurophysiological markers of clinical outcome in patients with TS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Tourette syndrome
  • Ages 13 - 18
  • Acceptance to perform the Brain MRI
  • Acceptance to perform the cognitive testing
  • Acceptance to perform the TMS measures

Exclusion criteria

  • Learning disability
  • Incompatibility with MRI procedure (metal body implants, pregnancy)

Treatment and study plan

Behavioral testing on cognitive computerized tasks

Behavioral

Testing on cognitive computerized tasks

Brain MRI

Other

Brain MRI scans

TMS

Other

Measure of the cortical inhibitory capacity using TMS measures

Primary outcomes

  1. Behavioral test main outcome measures [1]

    Time frame: from 16 to 20 months

    reaction times

  2. Behavioral test main outcome measures [2]

    Time frame: from 16 to 20 months

    discounting factor

  3. Behavioral test main outcome measures [3]

    Time frame: from 16 to 20 months

    number of premature responses

  4. Behavioral test main outcome measures [4]

    Time frame: from 16 to 20 months

    agency composite scores

  5. Brain MRI scan measures

    Time frame: from 16 to 20 months

    whole brain structural connectivity, whole brain functional connectivity, brain cortical and subcortical structures volumes and morphology

  6. Transcranial magnetic stimulation

    Time frame: from 16 to 20 months

    Short Intracortical Inhibition (SICI) scores

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Développement Cognitif et cérébral Chez Les Adolescents Souffrants d'un Syndrome de Gilles de la Tourette

Acronym: CADETS

Important dates

Study start
2019
Primary completion
2024
Study completion
2024
First posted
Nov 27, 2019
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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