Cognition Evolution and MRI Markers in PPMS Patients on 2 Years

Inclusion criteria

PATIENTS

• Male or female;
• Age ≥ 18 years;
• PPMS diagnosis according to McDonald 2010 criteria;
• Disease duration ≤ 15 years;
• Native French speaking;
• Being affiliated to health insurance;
• Willing to participate and to sign informed consent.

HEALTHY CONTROLS

• Male or Female;
• Age ≥ 18 years;
• Native French speaking;
• Being affiliated to health insurance;
• Willing to participate and to sign informed consent.

Exclusion criteria

PATIENTS

• previous history of other neurological disease;
• psychiatric comorbidity including severe depression according to DSM-IV;
• alcohol or other addiction to toxic;
• disabling visual or motor problems preventing participation to neuropsychological assessments;
• change of psychotropic drug since less than one month;
• contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body,claustrophobia or refusing MRI);
• illiteracy, is unable to count or to read;
• pregnant or breastfeeding women;
• patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).

HEALTHY CONTROLS

• history of neurological disease;
• family history of MS;
• psychiatric comorbidity including severe depression according to DSM-IV;
• alcohol or other toxic addiction;
• psychotropic drugs; known cognitive complaint or neuropsychological affection;
• prior neuropsychological testing with the same tests less than 6 months
• contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, meta fragments or foreign objects in the eyes, skin or body, claustrophobia or refusing MRI);
• illiteracy, is unable to count or to read;
• pregnant or breastfeeding women;
• person concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).