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Recruiting

NCT Number: NCT07220655

Cognition and Ultrasound

Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition

Recruiting

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Key information

Conditions

Healthy Participants

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location status: Recruiting

Location contact

Miriam Freedman

CONTACT

[email protected]

612-625-3330

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years of age or older
  • Speak English (as assessed by their ability to read/answer survey questions)
  • May be required to score in the appropriate range on self-report measures

Exclusion criteria

  • They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
  • They take any psychoactive medication.
  • They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
  • Are pregnant, or may have reason to believe that they are pregnant.
  • They have a diagnosis of a psychiatric condition other than depression or anxiety

Treatment and study plan

Low-Intensity Focused Ultrasound (FUS or LIFU)

Device

We will use an established, currently-marketed device to deliver LIFU neuromodulation.

Primary outcomes

  1. Deep Brain Targets Reached

    Time frame: Hour 1

    MRI-based readouts testing whether LIFU neuromodulation can successfully engage targets in deep brain

  2. Multi-Source Interference Test (MSIT) Performance

    Time frame: Hour 1

    Behavioral readouts of successful LIFU neuromodulation of our target regions

  3. 28/Posit Science Performance

    Time frame: Hour 1

    Behavioral readouts of successful LIFU neuromodulation of our target regions

Study contacts

Contact information is provided by the study sponsor or research team.

Miriam Freedman

CONTACT

[email protected]

tel:612-625-3330

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start
2024
Primary completion
2028
Study completion
2028
First posted
Oct 24, 2025
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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