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Completed

NCT Number: NCT02417519

Coffee Roasting and Glucose Tolerance

Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR) roasted coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Plasma glukose and insulin, appetite, and plasma and urine metabolic profiles will be analysed. The primary aim is to investigate whether roasting affects the postprandial glucose area under the curve (AUC).

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Key information

Conditions

Oral Glucose Tolerance Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutrition, Exercise and Sports, University of Copenhagen

Frederiksberg, 1958, Denmark

About this study

Epidemiologic evidence suggests that coffee consumption is associated with a lower risk of type 2 diabetes. Coffee contains caffeine and several other components that may modulate glucose regulation. The chlorogenic acids (CGA) in coffee have been indicated as constituents that may help to normalize the acute glucose response after a carbohydrate challenge. The aim of this study was to investigate whether two coffee beverages that differ in CGA content due to different roasting degrees will affect glucose regulation differently.

In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light roasted (LIR) or dark roasted (DAR) coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Blood samples were drawn at baseline, 30, 60 and 120 min. Differences in glucose and insulin responses and insulin sensitivity index (ISI) were analyzed. The CGA and caffeine contents in the coffees were analyzed using UPLC-MS/MS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Body mass index (BMI) of 18.0-30.0 kg/m2 and with no known diseases

Exclusion criteria

  • systemic infections,
  • psychiatric or metabolic disorders,
  • known food allergies or intolerances related to the products used in the study (e.g. dairy or gluten),
  • ongoing or former drug abuse,
  • high intake of alcohol (defined as a weekly intake of >7 units for women and > 14 units for men),
  • pregnancy or ongoing planning of pregnancy,
  • vegetarianism or veganism,
  • participation in other scientific studies during the study period, and
  • blood donation during - or in the month leading up to - the study period

Treatment and study plan

DAR

Other

Volunteers ingested 300 mL of coffee with a dark roast containing low levels of chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Other names: 300 mL of coffee with a dark roast + OGTT

LIR

Other

Volunteers ingested 300 mL of coffee with a light roast containing high levels of chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Other names: 300 mL of coffee with a light roast + OGTT

CTR

Other

Volunteers ingested 300 mL of water containing no chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Other names: 300 mL of water + OGTT

Primary outcomes

  1. Plasma glucose Area Under the Curve (Glucose AUC)

    Time frame: 0-120 min

    The area under the plasma glucose concentration curve was calculated from 0-120min after 75g glucose was ingested.

Secondary outcomes

  1. Plasma glucose concentrations

    Time frame: 30, 60 and120 min

    changes in the glucose concentration determined by a mixed model analysis and subsequently at each time point with time 0 as a co-variate.

  2. Serum Insulin Area Under the Curve

    Time frame: 0-120 min

    Area under the curve (AUC) for serum insulin

  3. Serum insulin concentrations

    Time frame: 30, 60 and120 min

    changes in the insulin concentration determined by a mixed model analysis and subsequently at each time point with time 0 as a co-variate.

  4. ISI(0-120)

    Time frame: 0-120min

    Matsuda's Insulin sensitivity index

  5. Metabolic profile in plasma

    Time frame: 0-24 hours

    Metabolic profile of plasma measured in all samples collected before the meal and postprandially from 0-120 min as well as in samples collected up to 24 hrs later.

  6. Metabolic profile in urine

    Time frame: 0-24 hours

    Metabolic profile of urine samples measured in all samples collected before the meal and postprandially from 0-120 min 120-240min as well as in samples collected up to 24 hrs later.

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Official study title

Acute Effects of Light and Dark Roasted Coffee on Glucose Tolerance: A Randomized, Controlled Crossover Trial in Healthy Volunteers

Important dates

Study start
2014
Primary completion
2014
Study completion
2015
First posted
Apr 15, 2015
Registry last updated
Dec 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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