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Active, Not Recruiting

NCT Number: NCT07011862

COBRA: Cancer, Older Adults, Balance and Resistance Activities

The purpose of this study is to find out whether an 8-week digital health promotion program called COBRA is a safe and practical (feasible) option for older adults with cancer/OAC.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Memorial Sloan Kettering Monmouth (Consent only), Middletown, New Jersey, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Older Adult Patients with Cancer

  • Are within 1 year of completion of primary therapy for cancer OR have a diagnosis of metastatic cancer;
  • For the purpose of this study, primary therapy is defined as treatment of curative intent, first-line or later, from which the individual is advancing to active surveillance or follow-up with or without maintenance therapy.
  • Individuals with metastatic cancer may be included provided they have stable disease or better per most recent restaging exam at time of enrollment.

i. Patients with stable metastatic bony disease at most recent restaging exam and a score of 0-2 on the Functional Pain Scale (FPS69; Appendix 18) are eligible. The PI will consult with the Rehab Med co-PI for FPS scores of 3 or greater, by patient request or PI discretion.

ii. Patients with symptomatic visceral metastases will be evaluated on a case-by-case basis at time of enrollment.

  • Are aged 65 years and older, with no upper age limit;
  • ECOG PS 0-3 or Karnofsky PS greater than or equal to 40;
  • Can read and speak English;
  • Self-report access to internet connection sufficient to support videoconferencing.

Clinicians

  • Licensed clinician (MD, RN, APP) with an interest in the care of older adults with cancer.

Exclusion criteria

Older Adult Patients with Cancer

  • Have any cognitive impairment, neurologic, musculoskeletal, or other comorbid condition (as assessed by their provider) that would prevent the individual from engaging with the digital health coaching program or complete study assessments or engage in progressive intensity levels of physical activity
  • Have a neurologic, musculoskeletal, or other comorbid condition that would impede their ability to safely engage in progressive intensity levels of physical activity (as assessed by their provider). Patients with metastatic disease and suspected interim progression since last restaging exam will be referred back to their primary oncology care team for evaluation prior to enrollment.
  • Have activity restrictions post-surgery at the time of enrollment

Clinicians No expected exclusions

Treatment and study plan

Cancer, Older adults, Balance and Resistance Activities

Behavioral

The COBRA intervention is delivered as a web-based application through an iPad configured to allow access only to the study application and Zoom videoconferencing icons during the trial.

Other names: COBRA

Primary outcomes

  1. Rate of retention and adherence to the COBRA/Cancer, Older Adults, Balance and Resistance Activities intervention

    Time frame: 8 weeks

    Rate of retention and adherence to the 8-week intervention to define intervention feasibility

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jun 10, 2025
Registry last updated
Apr 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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