Patients undergoing complex thoraco-abdominal aortic aneurysm repair
OtherPatients undergoing complex thoraco-abdominal aortic aneurysm repair
Recruiting
NCT Number: NCT06432387
Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair
This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Larissa University Hospital, Larissa, Thessaly, Greece
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About this study
Endovascular aneurysm repair of abdominal aorta activates a significant inflammation reaction and has an impact on coagulation. Platelet activation seems to have a major role in this prothrombotic and hypercoagulable state. In complex thoraco-abdominal aortic aneurysm repair the implants are more complexed and the duration of operation longer. The main hypothesis is that all the above have a greater impact on platelet activation and coagulation alterations.
The aim of this study is the evaluation of the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.
Exclusion criteria
- Refuse to participate
- Prior surgery within 3 months
- ASA PS > 3
- Known medical history of thrombophilia or functional platelet dysfunction
Treatment and study plan
Primary outcomes
-
Coagulation status
Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
-
Myocardial injury after non cardiac surgery
Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
-
Acute kidney injury
Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
-
Post-implantation syndrome
Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
-
Major cardiovascular events
Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day
Early preoperatively, early and late postoperatively
-
Major cardiovascular events, implant failure and death of any cause
Time frame: 30 days, 3, 6, and 12 months postoperatively
Early preoperatively, early and late postoperatively and 1 at one month
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University of Thessaly
Other
Registry information
Official study title
Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study
Acronym: CoFA-TAAA
Important dates
- Study start
- 2024
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- May 29, 2024
- Registry last updated
- May 7, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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