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Completed

NCT Number: NCT03803631

CNV in AMD Analyzed by OCT Angiography Under IntravitreaL Eylea (COCTAEyl)

The main objective of this study is to analyze a new noninvasive imaging examination, OCT angiography, in the evaluation of neovascular remodeling and early signs of recurrence of wet AMD undergoing treatment on OCTA and to correlate OCTA findings with SD-OCT findings.

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Key information

Conditions

AMD Exudative Macular Degeneration Eye Diseases Macular Degeneration Retinal Degeneration Retinal Diseases Wet Macular Degeneration

Age range

55 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Naïve patients
  • Type 1 or type 2 Choroidal NeoVascularization (CNV)
  • Age ≥ 55 years
  • Presence of subfoveal CNV secondary to Age-related Macular Degeneration (AMD)
  • At the time of inclusion, multimodal imaging should reveal exudative features
  • Exudative AMD diagnosis established between 1 and 7 days before inclusion
  • Monitored monthly
  • Loading phase then bimonthly retreatment.
  • Signed Informed Consent.
  • Patient covered by the French Health Insurance

Exclusion criteria

  • Polypoidal choroidal vasculopathy
  • Type 3 neovascularization
  • Choroidal neovascularization attributable to causes other than AMD
  • Macular hematoma
  • Pigment epithelial detachment higher than 150µm
  • Fibrosis > 50% lesion on fundus color photography, fibroglial scar
  • Media opacity annoying acquisition
  • Retinal vascular occlusion
  • Diabetic retinopathy
  • Adult-onset foveomacular vitelliform dystrophy and other pattern dystrophies,
  • Refractive error >-6D
  • Active intraocular inflammation in the study eye
  • Patient who does not meet the local indication criteria for Eylea® treatment. Contraindications listed in the SmPCs must be taken into account
  • Patient taking part in an interventional study at the time of enrolment.
  • Any history of allergy to the antiseptic used during preparation of the eye for the IVT injection in the investigational site (e.g. povidone iodine or chlorhexidine).
  • Pregnant and lactating women
  • Stroke and/or myocardial infarction 3 months before inclusion

Treatment and study plan

Primary outcomes

  1. presence of flow on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  2. presence of collaterals on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  3. presence of peripheral arcade on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  4. presence of arteriolization on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  5. presence of vascular loops on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  6. presence of dark halo on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  7. presence of feeder vessel on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  8. presence of flow void on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  9. measure of neovascular area on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  10. measure of neovascular density on OCTA

    Time frame: at month 13

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

Secondary outcomes

  1. presence of flow on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  2. presence of flow on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  3. presence of flow on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  4. presence of flow on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  5. presence of flow on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  6. presence of flow on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  7. presence of flow on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  8. presence of flow on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  9. presence of flow on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  10. presence of flow on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  11. presence of flow on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  12. presence of flow on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  13. presence of flow on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  14. presence of collaterals on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  15. presence of collaterals on OCTA

    Time frame: at month1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  16. presence of collaterals on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  17. presence of collaterals on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  18. presence of collaterals on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  19. presence of collaterals on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  20. presence of collaterals on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  21. presence of collaterals on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  22. presence of collaterals on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  23. presence of collaterals on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  24. presence of collaterals on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  25. presence of collaterals on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  26. presence of collaterals on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  27. presence of peripheral arcade on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  28. presence of peripheral arcade on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  29. presence of peripheral arcade on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  30. presence of peripheral arcade on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  31. presence of peripheral arcade on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  32. presence of peripheral arcade on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  33. presence of peripheral arcade on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  34. presence of peripheral arcade on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  35. presence of peripheral arcade on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  36. presence of peripheral arcade on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  37. presence of peripheral arcade on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  38. presence of peripheral arcade on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  39. presence of peripheral arcade on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  40. presence of arteriolization on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  41. presence of arteriolization on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  42. presence of arteriolization on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  43. presence of arteriolization on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  44. presence of arteriolization on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  45. presence of arteriolization on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  46. presence of arteriolization on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  47. presence of arteriolization on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  48. presence of arteriolization on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  49. presence of arteriolization on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  50. presence of arteriolization on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  51. presence of arteriolization on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  52. presence of vascular loops on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  53. presence of vascular loops on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  54. presence of vascular loops on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  55. presence of vascular loops on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  56. presence of vascular loops on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  57. presence of vascular loops on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  58. presence of vascular loops on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  59. presence of vascular loops on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  60. presence of vascular loops on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  61. presence of vascular loops on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  62. presence of vascular loops on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  63. presence of dark halo on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  64. presence of dark halo on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  65. presence of dark halo on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  66. presence of dark halo on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  67. presence of dark halo on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  68. presence of dark halo on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  69. presence of dark halo on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  70. presence of dark halo on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  71. presence of dark halo on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  72. presence of dark halo on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  73. presence of dark halo on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  74. presence of dark halo on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  75. presence of dark halo on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  76. presence of feeder vessel on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  77. presence of feeder vessel on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  78. presence of feeder vessel on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  79. presence of feeder vessel on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  80. presence of feeder vessel on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  81. presence of feeder vessel on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  82. presence of feeder vessel on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  83. presence of feeder vessel on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  84. presence of feeder vessel on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  85. presence of feeder vessel on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  86. presence of feeder vessel on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  87. presence of feeder vessel on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  88. presence of feeder vessel on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  89. presence of flow void on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  90. presence of flow void on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  91. presence of flow void on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  92. presence of flow void on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  93. presence of flow void on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  94. presence of flow void on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  95. presence of flow void on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  96. presence of flow void on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  97. presence of flow void on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  98. presence of flow void on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  99. presence of flow void on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  100. presence of flow void on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  101. presence of flow void on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  102. measure of neovascular area on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  103. measure of neovascular area on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  104. measure of neovascular area on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  105. measure of neovascular area on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  106. measure of neovascular area on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  107. measure of neovascular area on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  108. measure of neovascular area on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  109. measure of neovascular area on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  110. measure of neovascular area on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  111. measure of neovascular area on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  112. measure of neovascular area on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  113. measure of neovascular area on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  114. measure of neovascular area on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  115. measure of neovascular density on OCTA

    Time frame: baseline

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  116. measure of neovascular density on OCTA

    Time frame: at month 1

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  117. measure of neovascular density on OCTA

    Time frame: at month 2

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  118. measure of neovascular density on OCTA

    Time frame: at month 3

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  119. measure of neovascular density on OCTA

    Time frame: at month 4

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  120. measure of neovascular density on OCTA

    Time frame: at month 5

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  121. measure of neovascular density on OCTA

    Time frame: at month 6

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  122. measure of neovascular density on OCTA

    Time frame: at month 7

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  123. measure of neovascular density on OCTA

    Time frame: at month 8

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  124. measure of neovascular density on OCTA

    Time frame: at month 9

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  125. measure of neovascular density on OCTA

    Time frame: at month 10

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  126. measure of neovascular density on OCTA

    Time frame: at month 11

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  127. measure of neovascular density on OCTA

    Time frame: at month 12

    high flow on OCTA corresponding to the neovascular network with vascular remodeling over time

  128. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 13

  129. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at baseline

  130. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 1

  131. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 2

  132. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 3

  133. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 4

  134. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 5

  135. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 6

  136. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 7

  137. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 8

  138. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 9

  139. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 10

  140. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 11

  141. Intraretinal and/or subretinal fluid in SD-OCT

    Time frame: at month 12

  142. visual acuity in logmar

    Time frame: at baseline

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  143. visual acuity in logmar

    Time frame: at month 1

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  144. visual acuity in logmar

    Time frame: at month 2

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  145. visual acuity in logmar

    Time frame: at month 3

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  146. visual acuity in logmar

    Time frame: at month 4

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  147. visual acuity in logmar

    Time frame: at month 5

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  148. visual acuity in logmar

    Time frame: at month 6

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  149. visual acuity in logmar

    Time frame: at month 7

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  150. visual acuity in logmar

    Time frame: at month 8

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  151. visual acuity in logmar

    Time frame: at month 9

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  152. visual acuity in logmar

    Time frame: at month 10

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  153. visual acuity in logmar

    Time frame: at month 11

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  154. visual acuity in logmar

    Time frame: at month 12

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  155. visual acuity in logmar

    Time frame: at month 13

    Measure of best-corrected visual acuity (BCVA) measured on ETDRS

  156. presence or abscence of hemorrhage, fibrosis and atrophy on fundus color photography

    Time frame: at 1 months

  157. presence or abscence of hemorrhage on fundus color photography

    Time frame: at 1 months

  158. presence or abscence of fibrosis on fundus color photography

    Time frame: at 1 months

  159. presence or abscence of atrophy on fundus color photography

    Time frame: at 1 months

  160. presence or abscence of hemorrhage on fundus color photography

    Time frame: at 13 months

  161. presence or abscence of fibrosis on fundus color photography

    Time frame: at 13 months

  162. presence or abscence of atrophy on fundus color photography

    Time frame: at 13 months

  163. type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)

    Time frame: Baseline

  164. type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions)

    Time frame: at month 13

  165. type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)

    Time frame: baseline

  166. type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions)

    Time frame: at month 13

  167. choroidal thickness on EDI-OCT

    Time frame: monthly during 13 months

  168. type of choroidal neovascularization on SD-OCT (type 1, type 2 or mixed lesions)

    Time frame: monthly during 13 months

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal Creteil

Other

Collaborators

  • Bayer

Registry information

Acronym: COCTAEyl

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Jan 14, 2019
Registry last updated
Sep 2, 2025

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View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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