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OpenTrials
Completed

NCT Number: NCT01962584

CMR in Patients With Myocarditis

To evaluate the additive values of T1 mapping in patients with acute myocarditis.

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Key information

Conditions

Suspected Acute Myocarditis

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Bonn

Bonn, North Rhine-Westphalia, 53127, Germany

About this study

Cardiac magnetic resonance (CMR) is an established non-invasive diagnostic tool for acute and chronic myocarditis. Established CMR criteria for diagnosing myocarditis are edema on black-blood T2-weighted imaging, relative contrast enhancement seen on T1-weighted imaging for assessment of hyperemia, and late contrast-agent enhancement seen with inversion recovery late enhancement technique for visualization of myocardial fibrosis.

Recently, tissue characterization based on calculation of myocardial T1 relaxation time (T1 mapping) as well as T1-derived extracellular volume fraction has become available. Recently, reference values for myocardial T1 relaxation times at 3T for healthy volunteers were published for CMR. However, to date no comprehensive data for multiparametric CMR in patients with suspected myocarditis at 3 Tesla is available. Therefore, the purpose of this prospective study was to evaluate the diagnostic value of CMR at 3T in patients with suspected acute myocarditis using a multiparametric CMR approach including T1 mapping as novel tool for tissue characterization.

CMR will be performed within 7 days after hospital admission for "suspected acute myocarditis".

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with suspected acute myocarditis and otherwise unremarkable cardiac history

Exclusion criteria

  • exclusion of CAD in invasive coronary angiography
  • pregnancy
  • contraindications for MR imaging

Treatment and study plan

Primary outcomes

  1. T1 relaxation times

    Time frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis".

    quantification of T1 relaxation times

Secondary outcomes

  1. Extracellular volume (ECV)

    Time frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis".

    calculation of extracellular volume based on T1 relaxation time

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Value of CMR Including T1 Mapping in Patients With Acute Myocarditis

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Oct 14, 2013
Registry last updated
Dec 11, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.