CMR Features in Patients With Suspected Myocarditis

Presentation of myocarditis is heterogeneous, often ranges from being asymptomatic, to chest pain, dyspnoea, palpitations, and even sudden cardiac death. Diagnosing myocarditis is challenging with no current uniform clinical gold-standard. CMR is a key investigative tool, however the predictive value of CMR features is unknown. In this study we assess 670 consecutive patients with suspected myocarditis who were referred for CMR between 2002 and 2015 at the BWH. CMR features such as late gadolinium sizing, T1 mapping, extracellular volume fraction assessment, strain analysis (feature tracking), clinical data, labortory tetsings and electrocardiogramm are linked to the outcome in order to assess its predictive value.

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Key information

Conditions

Outcome, Fatal

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Brigham and Women's Hospital, Shapiro Cardiovascular Center

Boston, Massachusetts, 02115, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients referred by their treating physician to undergo CMR for "suspected myocarditis" as the primary clinical question

Exclusion criteria

evidence of coronary artery disease
hypertrophic cardiomyopathy
arrhythmogenic right ventricular cardiomyopathy
cardiac sarcoidosis
cardiac amyloidosis
takotsubo cardiomyopathy
constrictive pericarditis
Loeffler endocarditis
ventricular non-compaction
cardiac tumor
pulmonary embolism
severe valve disease

Treatment and study plan

cMR

Diagnostic Test

Outcome analysis of CMR features in suspected myocarditis patients

Primary outcomes

Major adverse cardiac events

Time frame: through study completion, an average of 2 years

Heart failure hospitalization; all cause death; sustained ventricular arrhythmia; recurrent myocarditis; transplantation

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Official study title

Predictive Value of CMR Features in Patients With Suspected Myocarditis

Acronym: CMRMyo

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2018
First posted: Mar 20, 2018
Registry last updated: Mar 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed