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NCT Number: NCT07018778

CMR-derived Quantitative Perfusion for Prediction of FFR

Patients will undergo quantitative perfusion assessment in cardiovascular magnetic resonance imaging (dual bolus or dual sequence approach) as well as invasive coronary angiography for assessment of fractional flow reserve (FFR) including assessment of coronary flow reserve (CFR) and microcirculatory resistance (IMR).

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Key information

Conditions

Chronic Coronary Syndrome

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kerckhoff Klinik

Bad Nauheim, Hesse, 61231, Germany

Location contact

Markus Schönburg

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical indication for vasodilatator CMR or invasive coronar angiography
  • capability to give informed consent

Exclusion criteria

  • general: non-compliance, <18 years of age, pregnancy
  • contraindications for CMR (non-CMR compatible device, chronic kidney disease (eGFR <30ml/min), allergies (medications)

Treatment and study plan

Primary outcomes

  1. Quantitative Perfusion

    Time frame: assessment of CMR and invasive data within 24hours

    Correlation of myocardial blood flow and perfusion reserve in CMR with invasively dervived fractional flow reserve (FFR), coronary flow reserve (CFR) and microcirculatory resistance (IMR)

  2. Dual bolus vs dual sequence

    Time frame: assessment of CMR and invasive data within 24hours

    Compare both CMR-derived quantitative perfusion for prediction of FFR/CFR/IMR

Secondary outcomes

  1. Strain

    Time frame: baseline CMR data

    Correlation of segmental perfusion and myocardial strain

  2. Tissue characterisation

    Time frame: baseline CMR data

    Correlation of segmental perfusion and T1/T2/ECV/LGE

  3. Cardiovascular Hospitalisation (CVH)

    Time frame: 12 months

    CVH within 12 months

Study contacts

Contact information is provided by the study sponsor or research team.

Andreas Rolf, MD

CONTACT

[email protected]

06032-996-2620

Sören Jan Backhaus, MD

CONTACT

[email protected]

06032-996-2620

Sponsors and collaborators

Lead sponsor

Kerckhoff Klinik

Other

Registry information

Official study title

Quantification of Myocardial Blood Flow in Cardiovascular Magnetic Resonance for Prediction of Fractional Flow Reserve in Coronary Catheterisation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 12, 2025
Registry last updated
Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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