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OpenTrials
Completed

NCT Number: NCT05777720

Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes

Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index case to susceptible contacts within the home.

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Key information

Conditions

Covid19 COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

San Mateo Medical Center, San Mateo, California, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Household members live in a shared space (apartment, home) with others (as opposed to renting single rooms in a shared space, for example)
  • At least 3 other people live in the household aside from index case

Exclusion criteria

  • If index case test positive day was over 2 days prior
  • If half or more household members are thought to be infected already
  • If household has fewer than 3 contacts interested in participating in the study
  • If fewer than 3 contacts are expected to be present in the house for a majority of the following 7 days

Treatment and study plan

Filtration Fan

Device

Investigators are using box fans with attached MERV16 filters, a design that has been tested and published in the scientific literature.

Safe-home pamphlet

Behavioral

The pamphlet has information on how the filtration fans work through visual images; and images of ventilation improvements in the home through opening windows.

Mid-week phone call

Behavioral

On day 3-4 of the study, the study coordinator assigned to the house will call and check in regarding the filtration fan usage and remind families about the importance of filtration and ventilation.

Primary outcomes

  1. Incidence of Covid19

    Time frame: 7th day since enrollment in the trial

    Investigators will measure the incidence of Covid19 in susceptible contacts on day 7.

Secondary outcomes

  1. Incidence of new upper respiratory symptoms

    Time frame: 7th day since enrollment in the trial

    Investigators will measure reported new upper respiratory symptoms in susceptible contacts.

  2. Average CO2 levels

    Time frame: 7 days

    Investigators will measure 7 day average CO2 levels in the home (measured in parts per million)

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

Registry information

Official study title

A Cluster-randomized Controlled Trial of Air Filtration and Ventilation Improvements to Reduce SARS CoV 2 Transmission Among Household Contacts

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Mar 21, 2023
Registry last updated
Feb 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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