Cluster Headache and SPINK-1 Gene

Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear.

The number of genetic association studies investigating variants implicated in the pathophysiology of CH is limited. The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms have been associated with CH. The former has been confirmed and may affect the hypothalamic hypocretin system. The aim of the present study was to investigate the possible link between SPINK 1 gene and cluster headache.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Episodic or Chronic Cluster Headache Brain Diseases Central Nervous System Diseases Cluster Headache Disease Attributes Headache Disorders Headache Disorders, Primary Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Trigeminal Autonomic Cephalalgias

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

APHM

Marseille, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

People aged 18 or over
Patient consulting in Marseille's or Nice's Pain departments
Patient agreeing to participate to the research study
Patient with health insurance

Exclusion criteria

People aged under 18
Patient refusing to participate to the research study
Patient with deprivation of liberty

Treatment and study plan

blood sample

Genetic

Primary outcomes

SPINK1 genotyping

Time frame: 2 months

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2013
Study completion: 2015
First posted: Oct 23, 2015
Registry last updated: Oct 23, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed