Closed-loop Anaesthesia for Liver Transplantation: a Pilot Study

Automated titration of propofol and remifentanil guided by the bispectral index (BIS) has been used for numerous surgical procedures. Orthotopic liver transplantation (OLT) uniquely combines major volaemic changes, an anhepatic phase, and ischaemia-reperfusion syndrome. We assessed the behaviour of this automated controller during OLT

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Key information

Conditions

Anesthesia Liver Transplant

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hopital Foch

Suresnes, 92150, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients scheduled for OLT

Exclusion criteria

age younger than 18 years, pregnancy, allergy or hypersensitivity to propofol or remifentanil, a medical history of psychiatric illness, and supraspinal neurological disorders

Treatment and study plan

Automated titration of propofol and remifentanil

Device

Calculation of Consumption of propofol and remifentanil

Primary outcomes

percentage of time spent in the BIS interval [40-60]

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Hopital Foch

Other

Registry information

Acronym: THConcentr

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Nov 30, 2017
Registry last updated: Nov 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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