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OpenTrials
Completed

NCT Number: NCT00730054

Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers

The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.

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Key information

Conditions

Acute Pain Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Sedation Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center

Oslo, 0027, Norway

About this study

To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

-

Treatment and study plan

Remifentanil+clonidine

Drug

iv Remifentanil+ iv clonidine

Other names: Ultiva, Catapressan

Primary outcomes

  1. Relief of pain(VAS reduction)

    Time frame: Experimental

Secondary outcomes

  1. Reduction in Minute ventilation

    Time frame: Experimental

  2. Reduction in CO2 stimulated Minute Ventilation

    Time frame: experimental

  3. Reduction in BIS score

    Time frame: Experimental

  4. Performance on Stroop test

    Time frame: Experimental

Sponsors and collaborators

Lead sponsor

Oslo University Hospital

Other

Registry information

Acronym: Remiclon

Important dates

Study start
2005
Primary completion
2005
Study completion
2005
First posted
Aug 8, 2008
Registry last updated
Jul 6, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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