The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Completed
NCT Number: NCT07263503
Clip and Coil in Fundal Gastric Varices With a Large Shunt
Endoscopic ultrasound (EUS)-guided coil deployment is a promising technique for the endoscopic management of gastric varices. However, coil migration may occur in patients with large drainage collaterals. This study aimed to evaluate the safety and efficacy of using clips in combination with coils for treating gastric varices. In this retrospective study, clips were placed before EUS-guided coil deployment in each patient with gastric varices and a large spontaneous portosystemic shunt. The pressure of gastric varices was directly measured by puncturing the varix with a needle connected to a pressure transducer, before and after clip placement. The occurrence of ectopic embolization or coil migration was recorded.
Completed
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Conditions
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- presence of a spontaneous portosystemic shunt, including gastrorenal or splenorenal collateral shunts;
- use of both clips and coils during endoscopic intervention.
Exclusion criteria
The spontaneous portosystemic shunt was narrow (diameter < 1.0 cm).
Treatment and study plan
Primary outcomes
-
The occurrence of ectopic embolization
Time frame: Within the day of the endoscopic intervention (after the operation)
Secondary outcomes
-
The occurrence of coil migration
Time frame: Within the day of the endoscopic intervention (after the operation)
Other outcomes
-
Gastric variceal pressure gradient
Time frame: During the endoscopic intervention
Sponsors and collaborators
Lead sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Other
Registry information
Official study title
Clip and Coil: A Novel Safe Strategy in Managing Fundal Gastric Varices With a Large Spontaneous Portosystemic Shunt
Important dates
- Study start
- 2024
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Dec 4, 2025
- Registry last updated
- Dec 4, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.