NCT Number: NCT06994689
A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death.
This study aims to investigate the clinimetric properties of a simple quadriceps perimetry and ShearWave elastography to improve the monitoring of skeletal muscle function in patients with COPD.
Interested in participating?
Request Info18 year and older
All sexes
Observational
Le Havre, 76290, France
Location status: Recruiting
Claire Dubois, PT
CONTACT
(+33)630039745
Claire Dubois, PT
PRINCIPAL_INVESTIGATOR
Yann Combret, PhD
CONTACT
(+33)686327255
Yann Combret, PhD
PRINCIPAL_INVESTIGATOR
Muscle dysfunction in COPD is characterized by reduced skeletal muscle mass and strength, particularly in the lower limbs. These systemic consequences of COPD play a key role in the course of these patients, through their impact on functional status, quality of life and increased mortality. Early detection and monitoring of muscular status in these patients could help improve management and limit the consequences of the disease.
Numerous studies show that variation in quadriceps mass has a significant relationship with premature mortality in this disease. The use of an indirect but simple and affordable measure: perimetric tape-measurement of thigh circumference, could help monitor quadriceps muscle mass in these patients on a regular and cost-effective basis. However, the clinimetric properties (validity, reliability, response to treatment) of this measurement need to be assessed to clarify its relevance.
On the other hand, ShearWave ® elastography (SWE) is a new method of measuring quadriceps stiffness. This measurement could provide additional information on muscle quality compared with conventional measures of strength or muscle trophicity. The potential added value of SWE ® for COPD patients has not yet been investigated. This tool would provide more precise indications of the state of the quadriceps, with the aim of improving the management of this pathology.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will undergo a pulmonary rehabilitation (PR) programme.
On day 1, perimetry and ShearWave measurements of the quadriceps muscle will be provided. Supplementary assessments of quadriceps thickness, quadriceps strength with a handheld dynamometry, lean body mass (bioelectrical impedance), constant work-rate endurance test and HAD questionnaire will also be provided on day 1.
The same measurements and questionnaire will be provided on the last day of the patient in the PR programme.
Other names: Functional exercice capacity, Quality of life, Bioelectrical impedance, Quadriceps thickness, Quadriceps strength : maximal voluntary contraction
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
Thigh circumference measured by a tape
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
ShearWave elastography of the quadriceps muscle
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
measured by bioelectrical impedance
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
measured as the endurance time during a constant load endurance test using a cycloergometer or a treadmill
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
measured by quality of life questionnaire (hospital anxiety and depression scale (HAD))
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
measured by ultrasonography
Time frame: At day 1 and after 5 weeks (at the end of the 5 weeks pulmonary rehabilitation program)
measure of maximal voluntary contraction with handheld dynamometry
Contact information is provided by the study sponsor or research team.
Claire Dubois, PT
CONTACT
(+33)630039745
Yann Combret, PhD
CONTACT
(+33)686327255
Groupe Hospitalier du Havre
Other
Clinimetric Properties Assessment of Quadriceps Muscle Mass and Stiffness Using Perimetry and ShearWave Elastography in Patients With COPD : a Prospective Observational Study
Acronym: Metriquad
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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